Sascha Feuerhahn
Overview
Explore the profile of Sascha Feuerhahn including associated specialties, affiliations and a list of published articles.
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9
Citations
587
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Recent Articles
1.
Feuerhahn S, Chen L, Luke B, Porro A
Trends Biochem Sci
. 2015 Apr;
40(5):275-85.
PMID: 25845889
Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence...
2.
Porro A, Feuerhahn S, Delafontaine J, Riethman H, Rougemont J, Lingner J
Nat Commun
. 2014 Nov;
5:5379.
PMID: 25359189
Telomere deprotection occurs during tumorigenesis and aging upon telomere shortening or loss of the telomeric shelterin component TRF2. Deprotected telomeres undergo changes in chromatin structure and elicit a DNA damage...
3.
Porro A, Feuerhahn S, Lingner J
Cell Rep
. 2014 Feb;
6(4):765-76.
PMID: 24529708
Telomeres protect chromosome ends from being recognized as sites of DNA damage. Upon telomere shortening or telomere uncapping induced by loss of telomeric repeat-binding factor 2 (TRF2), telomeres elicit a...
4.
Feuerhahn S, Giraudon C, Martinez-Diez M, Bueren-Calabuig J, Galmarini C, Gago F, et al.
Chem Biol
. 2011 Aug;
18(8):988-99.
PMID: 21867914
Trabectedin and Zalypsis are two potent anticancer tetrahydroisoquinoline alkaloids that can form a covalent bond with the amino group of a guanine in selected triplets of DNA duplexes and eventually...
5.
Porro A, Feuerhahn S, Reichenbach P, Lingner J
Mol Cell Biol
. 2010 Aug;
30(20):4808-17.
PMID: 20713443
Telomeres are transcribed into telomeric repeat-containing RNA (TERRA), large, heterogeneous, noncoding transcripts which form part of the telomeric heterochromatin. Despite a large number of functions that have been ascribed to...
6.
Feuerhahn S, Iglesias N, Panza A, Porro A, Lingner J
FEBS Lett
. 2010 Jul;
584(17):3812-8.
PMID: 20655916
Telomeres are heterochromatic structures at the ends of eukaryotic chromosomes. As other heterochromatin regions, telomeres are transcribed, from the subtelomeric region towards chromosome ends into the long non-coding RNA TERRA....
7.
Feuerhahn S, Egly J
Trends Genet
. 2008 Aug;
24(9):467-74.
PMID: 18675488
Our understanding of the DNA repair mechanisms that preserve genome integrity has increased greatly in recent years. To follow the DNA repair process, researchers have developed sophisticated techniques including live...
8.
Charlet-Berguerand N, Feuerhahn S, Kong S, Ziserman H, Conaway J, Conaway R, et al.
EMBO J
. 2006 Nov;
25(23):5481-91.
PMID: 17110932
Oxidative lesions represent the most abundant DNA lesions within the cell. In the present study, we investigated the impact of the oxidative lesions 8-oxoguanine, thymine glycol and 5-hydroxyuracil on RNA...
9.
Falsig J, Christiansen S, Feuerhahn S, Burkle A, Oei S, Keil C, et al.
Eur J Pharmacol
. 2004 Aug;
497(1):7-16.
PMID: 15321729
Poly(ADP-ribose) glycohydrolase (PARG) is being considered as a therapeutic target for the prevention of neurodegeneration. Here, we assessed the pharmacological tools available for target validation. The tannic acid derivative gallotannin...