Sarbjot Sachdeva
Overview
Explore the profile of Sarbjot Sachdeva including associated specialties, affiliations and a list of published articles.
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6
Citations
80
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Recent Articles
1.
Alhamadsheh M, Waters N, Sachdeva S, Lee P, Reynolds K
Bioorg Med Chem Lett
. 2008 Nov;
18(24):6402-5.
PMID: 18996691
A series of analogs of 2-tosylnaphthalene-1,4-diol were prepared and were found to be potent 10-20 nM reversible inhibitors of the Escherichia coli FabH enzyme. The inhibitors were also effective but...
2.
Sachdeva S, Reynolds K
Methods Mol Med
. 2008 Apr;
142:205-13.
PMID: 18437316
Fatty acid biosynthesis is one of the relatively newer targets in antibacterial drug discovery. The presence of distinct fatty acid synthases (FAS) in mammals and bacteria and the fact that...
3.
Sachdeva S, Musayev F, Alhamadsheh M, Scarsdale J, Wright H, Reynolds K
Chem Biol
. 2008 Apr;
15(4):402-12.
PMID: 18420147
Mycobacterium tuberculosis FabH initiates type II fatty acid synthase-catalyzed formation of the long chain (C(16)-C(22)) acyl-coenzyme A (CoA) precursors of mycolic acids, which are major constituents of the bacterial cell...
4.
Sachdeva S, Musayev F, Alhamadsheh M, Scarsdale J, Wright H, Reynolds K
Bioorg Chem
. 2007 Dec;
36(2):85-90.
PMID: 18096200
The dimeric Mycobacterium tuberculosis FabH (mtFabH) catalyses a Claisen-type condensation between an acyl-CoA and malonyl-acyl carrier protein (ACP) to initiate the Type II fatty acid synthase cycle. To analyze the...
5.
Alhamadsheh M, Musayev F, Komissarov A, Sachdeva S, Wright H, Scarsdale N, et al.
Chem Biol
. 2007 May;
14(5):513-24.
PMID: 17524982
The first step of the reaction catalyzed by the homodimeric FabH from a dissociated fatty acid synthase is acyl transfer from acyl-CoA to an active site cysteine. We report that...
6.
Musayev F, Sachdeva S, Scarsdale J, Reynolds K, Wright H
J Mol Biol
. 2005 Feb;
346(5):1313-21.
PMID: 15713483
Beta-ketoacyl-acyl carrier protein synthase III (FabH) catalyzes a two step reaction that initiates the pathway of fatty acid biosynthesis in plants and bacteria. In Mycobacterium tuberculosis, FabH catalyzes extension of...