Kevin A Reynolds
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Explore the profile of Kevin A Reynolds including associated specialties, affiliations and a list of published articles.
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64
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1019
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Recent Articles
1.
Kancharla P, Reynolds K
Tetrahedron
. 2024 Dec;
69(39):8375-8385.
PMID: 39619321
Facile, versatile and cost-effective synthetic routes for the preparation of a range of new 3-alkyl-, 4-alkyl-, 3,4-dialkyl-, and 3-halo-4-alkyl-2,2'-bipyrrole-5-carboxaldehydes have been developed. These 2,2'-bipyrrole-5-carboxaldehydes offer interesting potential as building blocks...
2.
Kumar A, Li Y, Dodean R, Roth A, Caridha D, Madejczyk M, et al.
ACS Infect Dis
. 2024 Nov;
10(12):4291-4300.
PMID: 39526703
Well-tolerated and novel antimalarials that can combat multiple stages of the parasite life cycle are desirable but challenging to discover and develop. Herein, we report results for natural product-inspired novel...
3.
Kumar A, Chithanna S, Li Y, Zhang X, Dodean R, Caridha D, et al.
J Med Chem
. 2024 Oct;
67(21):19755-19776.
PMID: 39425665
Malaria has been a deadly enemy of mankind throughout history, affecting over 200 million people annually, along with approximately half a million deaths. Resistance to current therapies is of great...
4.
Kancharla P, Ortiz D, Fargo C, Zhang X, Li Y, Sanchez M, et al.
J Med Chem
. 2024 May;
67(10):8323-8345.
PMID: 38722757
Leishmaniasis is a neglected tropical disease that is estimated to afflict over 12 million people. Current drugs for leishmaniasis suffer from serious deficiencies, including toxicity, high cost, modest efficacy, primarily...
5.
Kancharla P, Li Y, Yeluguri M, Dodean R, Reynolds K, Kelly J
J Med Chem
. 2021 Jun;
64(12):8739-8754.
PMID: 34111350
Highly efficient and straightforward synthetic routes toward the first total synthesis of 2-(-hydroxybenzyl)-prodigiosins (-), isoheptylprodigiosin (), and geometric isomers of tambjamine MYP1 ((/)-) have been developed. The crucial steps involved...
6.
Kancharla P, Dodean R, Li Y, Pou S, Pybus B, Melendez V, et al.
J Med Chem
. 2020 May;
63(11):6179-6202.
PMID: 32390431
The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent...
7.
Lu W, Kancharla P, Reynolds K
Org Lett
. 2017 Mar;
19(6):1298-1301.
PMID: 28271893
A novel bifunctional enzyme, MarH, has been identified, and its key functional role in the marineosin biosynthesis successfully probed. MarH catalyzes (1) a condensation step between 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC) and 2-undecylpyrrole...
8.
Kancharla P, Bonnett S, Reynolds K
Chembiochem
. 2016 May;
17(15):1426-9.
PMID: 27238740
The bacterial pathway of olefin biosynthesis starts with OleA catalyzed "head-to-head" condensation of two CoA-activated long-chain fatty acids to generate (R)-2-alkyl-3-ketoalkanoic acids. A subsequent OleD-catalyzed reduction generates (2R,3S)-2-alkyl-3-hydroxyalkanoic acids. We...
9.
Singh R, Reynolds K
J Nat Prod
. 2016 Jan;
79(1):240-3.
PMID: 26731437
FabA is proposed to catalyze the dehydration step of chain elongation in fatty acid and undecylprodiginine biosynthesis in Streptomyces coelicolor. Analysis of the S. coelicolor genome has revealed a fabA...
10.
Kancharla P, Kelly J, Reynolds K
J Med Chem
. 2015 Aug;
58(18):7286-309.
PMID: 26305125
Synthesis and antimalarial activity of 94 novel bipyrrole tambjamines (TAs) and a library of B-ring functionalized tripyrrole prodiginines (PGs) against a panel of Plasmodium falciparum strains are described. The activity...