Saravana K Ramasamy
Overview
Explore the profile of Saravana K Ramasamy including associated specialties, affiliations and a list of published articles.
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24
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3080
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Recent Articles
1.
Biswas L, Chen J, De Angelis J, Singh A, Owen-Woods C, Ding Z, et al.
Cell
. 2023 Jan;
186(2):382-397.e24.
PMID: 36669473
Blood and lymphatic vessels form a versatile transport network and provide inductive signals to regulate tissue-specific functions. Blood vessels in bone regulate osteogenesis and hematopoiesis, but current dogma suggests that...
2.
Rodrigues J, Wang Y, Singh A, Hendriks M, Dharmalingam G, Cohen-Solal M, et al.
Nat Cardiovasc Res
. 2022 Dec;
1:918-932.
PMID: 36531334
The mammalian skeletal system shows sex differences in structure, functions, ageing and disease incidences. The role of blood vessels in physiological, regenerative and pathological bone functions indicates the requisite to...
3.
Chen J, Sivan U, Tan S, Lippo L, De Angelis J, Labella R, et al.
Sci Adv
. 2021 Feb;
7(6).
PMID: 33536212
Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-associated vascular changes and their relation to tissue aging and pathology are poorly understood. Here, we perform 3D imaging of young...
4.
Hendriks M, Ramasamy S
Front Cell Dev Biol
. 2020 Dec;
8:602278.
PMID: 33330496
Recent advances in our understanding of blood vessels and vascular niches in bone convey their critical importance in regulating bone development and physiology. The contribution of blood vessels in bone...
5.
Chen J, Lippo L, Labella R, Tan S, Marsden B, Dustin M, et al.
EMBO J
. 2020 Nov;
40(1):e105242.
PMID: 33215738
Age-associated alterations of the hormone-secreting endocrine system cause organ dysfunction and disease states. However, the cell biology of endocrine tissue ageing remains poorly understood. Here, we perform comparative 3D imaging...
6.
Chen J, Hendriks M, Chatzis A, Ramasamy S, Kusumbe A
J Bone Miner Res
. 2020 Aug;
35(11):2103-2120.
PMID: 32845550
Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete angiocrine factors required for the survival, maintenance, and self-renewal of stem and progenitor cells. In the skeletal system,...
7.
Singh A, Veeriah V, Xi P, Labella R, Chen J, Romeo S, et al.
JCI Insight
. 2019 Jul;
4(13).
PMID: 31292293
Bone provides supportive microenvironments for hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) and is a frequent site of metastasis. While incidences of bone metastases increase with age, the...
8.
Romeo S, Alawi K, Rodrigues J, Singh A, Kusumbe A, Ramasamy S
Nat Cell Biol
. 2019 Apr;
21(4):430-441.
PMID: 30936475
Growth plate cartilage contributes to the generation of a large variety of shapes and sizes of skeletal elements in the mammalian system. The removal of cartilage and how this process...
9.
Duarte D, Hawkins E, Akinduro O, Ang H, De Filippo K, Kong I, et al.
Cell Stem Cell
. 2017 Dec;
22(1):64-77.e6.
PMID: 29276143
Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) cells produce angiogenic factors, which likely contribute...
10.
Ramasamy S
Stem Cells Int
. 2017 Nov;
2017:5046953.
PMID: 29104595
Bone provides nurturing microenvironments for an array of cell types that coordinate important physiological functions of the skeleton, such as energy metabolism, mineral homeostasis, osteogenesis, and haematopoiesis. Endothelial cells form...