Sarah Sargin
Overview
Explore the profile of Sarah Sargin including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
301
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0
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Recent Articles
1.
Becker S, Swoboda A, Siemer H, Schimmelpfennig S, Sargin S, Shahin V, et al.
Pflugers Arch
. 2024 Apr;
476(6):1007-1018.
PMID: 38613695
Neutrophil granulocytes play a crucial role in host defense against invading pathogens and in inflammatory diseases. The aim of this study was to elucidate membrane potential dynamics during the initial...
2.
Petho Z, Najder K, Beel S, Fels B, Neumann I, Schimmelpfennig S, et al.
JCI Insight
. 2023 Aug;
8(19).
PMID: 37643024
Pancreatic ductal adenocarcinoma (PDAC) progresses in an organ with a unique pH landscape, where the stroma acidifies after each meal. We hypothesized that disrupting this pH landscape during PDAC progression...
3.
Fuest S, Post C, Balbach S, Jabar S, Neumann I, Schimmelpfennig S, et al.
Cancers (Basel)
. 2022 Oct;
14(19).
PMID: 36230742
Ewing sarcoma (EwS) is a rare and highly malignant bone tumor occurring mainly in childhood and adolescence. Physiologically, the bone is a central hub for Ca homeostasis, which is severely...
4.
Oster L, Schroder J, Rugi M, Schimmelpfennig S, Sargin S, Schwab A, et al.
J Immunol
. 2022 Jun;
209(1):136-144.
PMID: 35715008
Neutrophil granulocytes are the first and robust responders to the chemotactic molecules released from an inflamed acidic tissue. The aim of this study was to elucidate the role of microenvironmental...
5.
Najder K, Rugi M, Lebel M, Schroder J, Oster L, Schimmelpfennig S, et al.
Front Immunol
. 2020 Oct;
11:2124.
PMID: 33013896
The importance of the intracellular Ca concentration ([Ca]) in neutrophil function has been intensely studied. However, the role of the intracellular Na concentration ([Na]) which is closely linked to the...
6.
Kuntze A, Goetsch O, Fels B, Najder K, Unger A, Wilhelmi M, et al.
Front Physiol
. 2020 Mar;
11:89.
PMID: 32116794
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an acidic and fibrotic stroma. The extracellular matrix (ECM) causing the fibrosis is primarily formed by pancreatic stellate cells (PSCs). The effects of...
7.
Nielsen N, Kondratska K, Ruck T, Hild B, Kovalenko I, Schimmelpfennig S, et al.
Pflugers Arch
. 2017 Aug;
469(12):1567-1577.
PMID: 28849300
Pancreatic cancer is characterized by a massive fibrosis (desmoplasia), which is primarily caused by activated pancreatic stellate cells (PSCs). This leads to a hypoxic tumor microenvironment further reinforcing the activation...
8.
Storck H, Hild B, Schimmelpfennig S, Sargin S, Nielsen N, Zaccagnino A, et al.
Oncotarget
. 2016 Dec;
8(1):769-784.
PMID: 27903970
Pancreatic stellate cells (PSCs) play a critical role in the progression of pancreatic ductal adenocarcinoma (PDAC). Once activated, PSCs support proliferation and metastasis of carcinoma cells. PSCs even co-metastasise with...
9.
Hanley P, Kronlage M, Kirschning C, Del Rey A, Di Virgilio F, Leipziger J, et al.
J Biol Chem
. 2012 Jan;
287(13):10650-10663.
PMID: 22235111
The function of P2X(7) receptors (ATP-gated ion channels) in innate immune cells is unclear. In the setting of Toll-like receptor (TLR) stimulation, secondary activation of P2X(7) ion channels has been...
10.
Isfort K, Ebert F, Bornhorst J, Sargin S, Kardakaris R, Pasparakis M, et al.
J Biol Chem
. 2011 Nov;
286(52):44776-87.
PMID: 22057273
Adenosine 5'-triphosphate (ATP) has been implicated in the recruitment of professional phagocytes (neutrophils and macrophages) to sites of infection and tissue injury in two distinct ways. First, ATP itself is...