Sarah J Marzi
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Explore the profile of Sarah J Marzi including associated specialties, affiliations and a list of published articles.
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19
Citations
324
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Recent Articles
1.
Murphy A, Askarova A, Lenhard B, Skene N, Marzi S
Nucleic Acids Res
. 2024 Dec;
53(4).
PMID: 39660643
To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based on large-scale machine learning models. However, these approaches have omitted...
2.
Marzi S, Schilder B, Nott A, Sala Frigerio C, Willaime-Morawek S, Bucholc M, et al.
Alzheimers Dement
. 2023 Sep;
19(12):5970-5987.
PMID: 37768001
Introduction: Experimental models are essential tools in neurodegenerative disease research. However, the translation of insights and drugs discovered in model systems has proven immensely challenging, marred by high failure rates...
3.
Winchester L, Harshfield E, Shi L, Badhwar A, Al Khleifat A, Clarke N, et al.
Alzheimers Dement
. 2023 Sep;
19(12):5860-5871.
PMID: 37654029
With the increase in large multimodal cohorts and high-throughput technologies, the potential for discovering novel biomarkers is no longer limited by data set size. Artificial intelligence (AI) and machine learning...
4.
Bucholc M, James C, Al Khleifat A, Badhwar A, Clarke N, Dehsarvi A, et al.
Alzheimers Dement
. 2023 Aug;
19(12):5934-5951.
PMID: 37639369
Artificial intelligence (AI) and machine learning (ML) approaches are increasingly being used in dementia research. However, several methodological challenges exist that may limit the insights we can obtain from high-dimensional...
5.
Tsalenchuk M, Gentleman S, Marzi S
NPJ Parkinsons Dis
. 2023 Aug;
9(1):123.
PMID: 37626097
Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a complex risk structure thought to be influenced by interactions between genetic variants and environmental exposures, although the full aetiology...
6.
Bettencourt C, Skene N, Bandres-Ciga S, Anderson E, Winchester L, Foote I, et al.
Alzheimers Dement
. 2023 Aug;
19(12):5905-5921.
PMID: 37606627
Genetics and omics studies of Alzheimer's disease and other dementia subtypes enhance our understanding of underlying mechanisms and pathways that can be targeted. We identified key remaining challenges: First, can...
7.
Bucholc M, James C, Al Khleifat A, Badhwar A, Clarke N, Dehsarvi A, et al.
ArXiv
. 2023 Mar;
PMID: 36911275
Introduction: Machine learning (ML) has been extremely successful in identifying key features from high-dimensional datasets and executing complicated tasks with human expert levels of accuracy or greater. Methods: We summarize...
8.
Rodriguez-Algarra F, Seaborne R, Danson A, Yildizoglu S, Yoshikawa H, Law P, et al.
Genome Biol
. 2022 Feb;
23(1):54.
PMID: 35164830
Background: Ribosomal DNA (rDNA) displays substantial inter-individual genetic variation in human and mouse. A systematic analysis of how this variation impacts epigenetic states and expression of the rDNA has thus...
9.
Cerase A, Young A, Ruiz N, Buness A, Sant G, Arnold M, et al.
Commun Biol
. 2021 Apr;
4(1):485.
PMID: 33859315
Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist, an X-linked long non-coding RNA (lncRNA). At the onset...
10.
Smith A, Smith R, Macdonald R, Marzi S, Burrage J, Troakes C, et al.
Future Sci OA
. 2021 Apr;
7(4):FSO665.
PMID: 33815817
Several epigenome-wide association studies of DNA methylation have highlighted altered DNA methylation in the gene in Alzheimer's disease (AD) brain samples. However, no study has specifically examined histone modifications in...