Sarah C Durand
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Explore the profile of Sarah C Durand including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
540
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Recent Articles
1.
Crouchet E, Almeida N, Durand S, Parnot M, Oudot M, Giannone F, et al.
JHEP Rep
. 2025 Feb;
7(2):101252.
PMID: 39897611
Background & Aims: Hepatocellular carcinoma (HCC) is the third-leading and fastest rising cause of cancer-related death worldwide. The discovery and preclinical development of compounds targeting HCC are hampered by the...
2.
Mukherji A, Juhling F, Simanjuntak Y, Crouchet E, Del Zompo F, Teraoka Y, et al.
Nat Commun
. 2024 Aug;
15(1):7486.
PMID: 39209804
Chronic liver disease and cancer are global health challenges. The role of the circadian clock as a regulator of liver physiology and disease is well established in rodents, however, the...
3.
Crouchet E, Dachraoui M, Juhling F, Roehlen N, Oudot M, Durand S, et al.
J Hepatol
. 2024 Aug;
82(1):120-133.
PMID: 39173955
Background & Aims: Liver fibrosis is the major driver of hepatocellular carcinoma and liver disease-related death. Approved antifibrotic therapies are absent and compounds in development have limited efficacy. Increased TGF-β...
4.
Roehlen N, Saviano A, El Saghire H, Crouchet E, Nehme Z, Del Zompo F, et al.
Sci Transl Med
. 2022 Dec;
14(676):eabj4221.
PMID: 36542691
Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need...
5.
Roehlen N, Muller M, Nehme Z, Crouchet E, Juhling F, Del Zompo F, et al.
J Hepatol
. 2022 Oct;
78(2):343-355.
PMID: 36309131
Background & Aims: Despite recent approvals, the response to treatment and prognosis of patients with advanced hepatocellular carcinoma (HCC) remain poor. Claudin-1 (CLDN1) is a membrane protein that is expressed...
6.
Crouchet E, Li S, Sojoodi M, Bandiera S, Fujiwara N, El Saghire H, et al.
JCI Insight
. 2022 Jul;
7(13).
PMID: 35801591
Hepatocellular carcinoma (HCC) is a leading cause of death among cirrhotic patients, for which chemopreventive strategies are lacking. Recently, we developed a simple human cell-based system modeling a clinical prognostic...
7.
Crouchet E, Bandiera S, Fujiwara N, Li S, El Saghire H, Fernandez-Vaquero M, et al.
Nat Commun
. 2021 Sep;
12(1):5525.
PMID: 34535664
Chronic liver disease and hepatocellular carcinoma (HCC) are life-threatening diseases with limited treatment options. The lack of clinically relevant/tractable experimental models hampers therapeutic discovery. Here, we develop a simple and...
8.
Juhling F, Saviano A, Ponsolles C, Heydmann L, Crouchet E, Durand S, et al.
Life Sci Alliance
. 2021 Jul;
4(9).
PMID: 34290079
Chronic hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma (HCC) world-wide. The molecular mechanisms of viral hepatocarcinogenesis are still partially understood. Here, we applied two complementary...
9.
Herzog K, Bandiera S, Pernot S, Fauvelle C, Juhling F, Weiss A, et al.
Gut
. 2019 May;
69(2):380-392.
PMID: 31076402
Objective: Infection of human hepatocytes by the hepatitis C virus (HCV) is a multistep process involving both viral and host factors. microRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate...
10.
Lupberger J, Croonenborghs T, Roca Suarez A, Van Renne N, Juhling F, Oudot M, et al.
Gastroenterology
. 2019 Apr;
157(2):537-551.e9.
PMID: 30978357
Background & Aims: The mechanisms of hepatitis C virus (HCV) infection, liver disease progression, and hepatocarcinogenesis are only partially understood. We performed genomic, proteomic, and metabolomic analyses of HCV-infected cells...