Sara Santagata
Overview
Explore the profile of Sara Santagata including associated specialties, affiliations and a list of published articles.
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20
Citations
337
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0
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Recent Articles
1.
Trotta A, Mazzarella V, Roggia M, DAniello A, Bene A, Vetrei C, et al.
Eur J Med Chem
. 2024 Sep;
279:116911.
PMID: 39348763
Macrocyclization presents a valuable strategy for enhancing the pharmacokinetic and pharmacodynamic profiles of short bioactive peptides. The exploration of various macrocyclic characteristics, such as crosslinking tethers, ring size, and orientation,...
2.
Portella L, Bertolini G, Guardascione G, Di Febbraro D, Ierano C, DAlterio C, et al.
Heliyon
. 2024 Aug;
10(15):e35524.
PMID: 39170328
Background: Circulating Tumor Cells (CTCs) represent a small, heterogeneous population that comprise the minority of cells able to develop metastasis. To trap and characterize CTCs with metastatic attitude, a CXCL12-loaded...
3.
Santagata S, Trotta A, DAlterio C, Napolitano M, Rea G, Di Napoli M, et al.
Clin Cancer Res
. 2024 Aug;
30(20):4755-4767.
PMID: 39167621
Purpose: To identify predictive factors of nivolumab sensitivity, peripheral blood NKs and regulatory T-cell (Treg) were evaluated in patients with metastatic renal cell carcinoma (mRCC) enrolled in the REVOLUTION trial....
4.
Santagata S, Rea G, Bello A, Capiluongo A, Napolitano M, Desicato S, et al.
Br J Cancer
. 2024 May;
130(12):2016-2026.
PMID: 38704478
Background: Tregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in peripheral blood (PB)-Tregs isolated from primary RCC...
5.
Ottaiano A, De Luca A, Santorsola M, Scognamiglio G, Di Mauro A, Chiodini P, et al.
BMC Cancer
. 2023 Oct;
23(1):1010.
PMID: 37858132
Background: Metastatic disease in tumors originating from the gastrointestinal tract can exhibit varying degrees of tumor burden at presentation. Some patients follow a less aggressive disease course, characterized by a...
6.
Santagata S, Rea G, Castaldo D, Napolitano M, Capiluongo A, DAlterio C, et al.
Hepatol Int
. 2023 May;
18(2):568-581.
PMID: 37142825
Background And Purpose: While HCC is an inflammation-associated cancer, CRLM develops on permissive healthy liver microenvironment. To evaluate the immune aspects of these two different environments, peripheral blood-(PB), peritumoral-(PT) and...
7.
Ierano C, Righelli D, DAlterio C, Napolitano M, Portella L, Rea G, et al.
J Immunother Cancer
. 2022 Mar;
10(3).
PMID: 35246475
Background: Colorectal cancer (CRC) is one of the most prevalent and deadly tumors worldwide. The majority of CRC is resistant to anti-programmed cell death-1 (PD-1)-based cancer immunotherapy, with approximately 15%...
8.
Ottaiano A, Petito A, Santorsola M, Gigantino V, Capuozzo M, Fontanella D, et al.
Cancers (Basel)
. 2021 Aug;
13(16).
PMID: 34439390
Background: in recent years, the management of advanced colorectal cancer (CRC) has been greatly improved with integrated strategies including stereotactic radiation therapy (SRT). The administration of SRT has been demonstrated,...
9.
Santagata S, Ierano C, Trotta A, Capiluongo A, Auletta F, Guardascione G, et al.
Front Oncol
. 2021 May;
11:591386.
PMID: 33937018
The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors (GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They play a key role in the tumor/tumor...
10.
Trotta A, Aurilio M, DAlterio C, Ierano C, Di Martino D, Barbieri A, et al.
J Med Chem
. 2021 Mar;
64(6):3449-3461.
PMID: 33660512
The recently reported CXCR4 antagonist (Ac-Arg-Ala-[DCys-Arg-2Nal-His-Pen]-COH) was investigated as a molecular scaffold for a CXCR4-targeted positron emission tomography (PET) tracer. Toward this end, was functionalized with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and...