Sara Linker
Overview
Explore the profile of Sara Linker including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
11
Citations
146
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0
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Recent Articles
1.
Tan P, Ostertag T, Rosenthal S, Chilin-Fuentes D, Aidnik H, Linker S, et al.
Am J Pathol
. 2023 Dec;
194(3):353-368.
PMID: 38158078
Nonalcoholic steatohepatitis (NASH) is an inflammatory and fibrotic liver disease that has reached epidemic proportions and has no approved pharmacologic therapies. Research and drug development efforts are hampered by inadequate...
2.
Shen W, Wang Q, Liu Y, Marchetto M, Linker S, Lu S, et al.
Proc Natl Acad Sci U S A
. 2020 Feb;
117(8):4392-4399.
PMID: 32041882
The pathogenesis of bipolar disorder (BD) has remained enigmatic, largely because genetic animal models based on identified susceptible genes have often failed to show core symptoms of spontaneous mood cycling....
3.
Stern S, Linker S, Vadodaria K, Marchetto M, Gage F
Focus (Am Psychiatr Publ)
. 2020 Feb;
17(3):294-307.
PMID: 32015721
Reprinted with permission from . 8: 180031. The Royal Society.
4.
Vadodaria K, Jones J, Linker S, Gage F
Cold Spring Harb Perspect Biol
. 2019 Nov;
12(6).
PMID: 31767646
Brain disorders, from neurodegenerative to psychiatric disorders, are among the most challenging conditions to study because of the intricate nature of the human brain and the limitations of existing model...
5.
Stern S, Linker S, Vadodaria K, Marchetto M, Gage F
Open Biol
. 2018 May;
8(5).
PMID: 29794033
Personalized medicine has become increasingly relevant to many medical fields, promising more efficient drug therapies and earlier intervention. The development of personalized medicine is coupled with the identification of biomarkers...
6.
Linker S, Hedges D
PLoS One
. 2018 Jan;
9(1).
PMID: 29364980
[This corrects the article DOI: 10.1371/journal.pone.0079402.].
7.
Bedrosian T, Linker S, Gage F
Genome Med
. 2016 May;
8(1):58.
PMID: 27215330
The identification of somatic mosaicism in the brain lends a new perspective to our understanding of the role of gene and environment interactions in psychiatric disease risk. Somatic mutations, such...
8.
Streva V, Jordan V, Linker S, Hedges D, Batzer M, Deininger P
BMC Genomics
. 2015 Apr;
16:220.
PMID: 25887476
Background: There are over a half a million copies of L1 retroelements in the human genome which are responsible for as much as 0.5% of new human genetic diseases. Most...
9.
Kim S, Oceguera-Yanez F, Hirohata R, Linker S, Okita K, Yamada Y, et al.
Stem Cell Reports
. 2015 Mar;
4(4):727-43.
PMID: 25772473
As the quintessential reprogramming model, OCT3/4, SOX2, KLF4, and c-MYC re-wire somatic cells to achieve induced pluripotency. Yet, subtle differences in methodology confound comparative studies of reprogramming mechanisms. Employing transposons,...
10.
Linker S, Hedges D
PLoS One
. 2013 Nov;
8(11):e79402.
PMID: 24244495
Retrotransposons comprise approximately half of the human genome and contribute to chromatin structure, regulatory motifs, and protein-coding sequences. Since retrotransposon insertions can disrupt functional genetic elements as well as introduce...