Sara L OKane
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Explore the profile of Sara L OKane including associated specialties, affiliations and a list of published articles.
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10
Citations
169
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Recent Articles
1.
Murphy M, OConnell D, OKane S, OBrien J, OToole S, Martin C, et al.
J Proteomics
. 2012 Mar;
75(15):4668-75.
PMID: 22415278
Autoantibodies represent an attractive biomarker for diagnostic assays principally due to the stability of immunoglobulin in patient serum facilitating measurement with conventional assays. Immune responses to tumorigenesis may facilitate detection...
2.
OKane S, OBrien J, Cahill D
Methods Mol Biol
. 2011 Sep;
785:331-41.
PMID: 21901610
Profiling the autoantibody (AAb) repertoire in serum has been routinely used for many years for the diagnosis of autoimmune diseases, including rheumatoid arthritis, scleroderma, and lupus. In recent years, AAb...
3.
OConnell D, Bauer M, OBrien J, Johnson W, Divizio C, OKane S, et al.
Mol Cell Proteomics
. 2010 Jan;
9(6):1118-32.
PMID: 20068228
Calmodulin is an essential regulator of intracellular processes in response to extracellular stimuli mediated by a rise in Ca(2+) ion concentration. To profile protein-protein interactions of calmodulin in human brain,...
4.
OKane S, Eagle G, Greenman J, Lind M, Cawkwell L
Lung Cancer
. 2009 May;
67(2):160-5.
PMID: 19450893
Background: Although malignant pleural mesothelioma is a rare tumour, its incidence is increasing. The prognosis remains very poor with an average survival of 10 months from diagnosis. The choice of...
5.
Smith L, Watson M, OKane S, Drew P, Lind M, Cawkwell L
Mol Cancer Ther
. 2006 Aug;
5(8):2115-20.
PMID: 16928833
Doxorubicin is considered to be the most effective agent in the treatment of breast cancer patients. Unfortunately, resistance to this agent is common, representing a major obstacle to successful treatment....
6.
OKane S, Pound R, Campbell A, Chaudhuri N, Lind M, Cawkwell L
Acta Oncol
. 2006 Jun;
45(4):449-53.
PMID: 16760181
Little is known about the Bcl-2 family members in mesothelioma. These proteins are involved in the control of apoptosis, carrying out both pro- and anti- apoptotic functions. Immunohistochemistry was used...
7.
Sivarajasingham N, Cawkwell L, Baker R, OKane S, Smyth E, Tilsed J, et al.
Ann Surg Oncol
. 2006 Apr;
13(6):881-6.
PMID: 16614877
Background: Although BRCA genes have been implicated in certain tumors, particularly breast tumors, their role in colon tumorigenesis has not been fully explored. We aimed to investigate the association of...
8.
Smith L, Berrieman H, OKane S, Campbell A, Maraveyas A, Cawkwell L
Oncol Res
. 2006 Mar;
15(9):441-4.
PMID: 16555550
Apoptosis proteins may play a role in prognosis and therapy response; however, they have not been fully investigated in gastric cancer. We aimed to assess the expression of proteins in...
9.
Berrieman H, Cawkwell L, OKane S, Smith L, Lind M
Oncol Rep
. 2005 Dec;
15(1):283-6.
PMID: 16328069
One of the most valuable objectives for oncologists is the ability to predict patient response to chemotherapy before drugs are administered in order to maximise the therapeutic benefit of treatment...
10.
Berrieman H, Smith L, OKane S, Campbell A, Lind M, Cawkwell L
Cancer
. 2005 Feb;
103(7):1415-9.
PMID: 15700269
Background: Proteins of the Bcl-2 family play a key role in the control of apoptosis and carry out both proapoptotic and antiapoptotic functions. However, with the exception of Bcl-2 itself,...