John K OBrien
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Explore the profile of John K OBrien including associated specialties, affiliations and a list of published articles.
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9
Citations
73
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Recent Articles
1.
Murphy M, OConnell D, OKane S, OBrien J, OToole S, Martin C, et al.
J Proteomics
. 2012 Mar;
75(15):4668-75.
PMID: 22415278
Autoantibodies represent an attractive biomarker for diagnostic assays principally due to the stability of immunoglobulin in patient serum facilitating measurement with conventional assays. Immune responses to tumorigenesis may facilitate detection...
2.
OKane S, OBrien J, Cahill D
Methods Mol Biol
. 2011 Sep;
785:331-41.
PMID: 21901610
Profiling the autoantibody (AAb) repertoire in serum has been routinely used for many years for the diagnosis of autoimmune diseases, including rheumatoid arthritis, scleroderma, and lupus. In recent years, AAb...
3.
Gibson D, Banha J, Penque D, Costa L, Conrads T, Cahill D, et al.
J Proteomics
. 2009 Dec;
73(6):1045-60.
PMID: 19995622
Current clinical, laboratory or radiological parameters cannot accurately diagnose or predict disease outcomes in a range of autoimmune disorders. Biomarkers which can diagnose at an earlier time point, predict outcome...
4.
Moore N, Dicker P, OBrien J, Stojanovic M, Conroy R, Treumann A, et al.
Hypertension
. 2007 Jun;
50(2):340-7.
PMID: 17562974
Renin catalyzes the rate-limiting step of the renin-angiotensin system. A T allele variant at position -5312 within a distal enhancer region has been reported to increase in vitro renin gene...
5.
OHalloran A, Curtin R, OConnor F, Dooley M, Fitzgerald A, OBrien J, et al.
Br J Haematol
. 2006 Jan;
132(4):494-502.
PMID: 16412022
Some studies have suggested that genetic variability in the glycoprotein (GP) IIIa gene modulates expression of platelet GPIIb/IIIa (alpha(2b)beta(3)). We sought to determine as to whether combinations of genetic variants...
6.
Dolan C, Shields D, Stanton A, OBrien E, Lambert D, OBrien J, et al.
BMC Med Genet
. 2005 Dec;
6:41.
PMID: 16324215
Background: The recessive disorder trimethylaminuria is caused by defects in the FMO3 gene, and may be associated with hypertension. We investigated whether common polymorphisms of the FMO3 gene confer an...
7.
Dolan C, OHalloran A, Bradley D, Croke D, Evans A, OBrien J, et al.
Eur J Hum Genet
. 2005 Mar;
13(7):798-806.
PMID: 15785776
Selection pressures from pathogens impact on the worldwide geographic distribution of polymorphisms in certain pathogen-response-associated genes. Such gene-specific effects could lead to confounding by geographic disease associations. We wished to...
8.
Malecova B, Ramser J, OBrien J, Janitz M, Judova J, Lehrach H, et al.
Gene
. 2003 Feb;
303:165-75.
PMID: 12559578
Mrjp1 gene belongs to the honeybee mrjp gene family encoding the major royal jelly proteins (MRJPs), secreted by nurse bees into the royal jelly. In this study, we have isolated...
9.
Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al.
Genomics
. 2002 Sep;
80(3):295-302.
PMID: 12213199
We developed a novel efficient scheme, DEFOG (for "deciphering families of genes"), for determining sequences of numerous genes from a family of interest. The scheme provides a powerful means to...