Sara J Thygesen
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Explore the profile of Sara J Thygesen including associated specialties, affiliations and a list of published articles.
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12
Citations
215
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Recent Articles
1.
Rahaman M, Thygesen S, Maxwell M, Kim H, Mudai P, Nanson J, et al.
J Enzyme Inhib Med Chem
. 2024 Feb;
39(1):2313055.
PMID: 38416868
Toll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged signalling contributes to a range of inflammatory conditions. Structural information on the TLR cytoplasmic TIR (Toll/interleukin-1 receptor)...
2.
Thygesen S, Burgener S, Mudai P, Monteleone M, Boucher D, Sagulenko V, et al.
Eur J Immunol
. 2024 Feb;
54(5):e2350515.
PMID: 38361219
Caspase-1 location in cells has been studied with fluorochrome-labeled inhibitors of caspase-1 (FLICA reagents). We report that FLICA reagents have limited cell-membrane permeability. This impacts experimental design as cells with...
3.
Pliego Zamora A, Kim J, Vajjhala P, Thygesen S, Watterson D, Modhiran N, et al.
J Virol
. 2023 Oct;
97(11):e0125123.
PMID: 37850747
Dengue virus, an arbovirus, causes an estimated 100 million symptomatic infections annually and is an increasing threat as the mosquito range expands with climate change. Dengue epidemics are a substantial...
4.
Clabbers M, Holmes S, Muusse T, Vajjhala P, Thygesen S, Malde A, et al.
Nat Commun
. 2021 May;
12(1):2578.
PMID: 33972532
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MAL) forms filaments in vitro and...
5.
Thygesen S, Pliego-Zamora A, Stacey K
EMBO J
. 2020 Sep;
39(17):e106202.
PMID: 32869315
Shigella, a major cause of bacterial dysentery, knows when it is not wanted. To generate and maintain its niche within host cells, this unwelcome guest injects several dozen virulence factors...
6.
Thygesen S, Stacey K
EMBO Rep
. 2019 Aug;
20(9):e48891.
PMID: 31379068
The non-canonical inflammasome mediates pyroptotic cell death in response to bacterial lipopolysaccharide (LPS) found in the cytosol. Understanding the mechanism and regulation of this system is of great interest, given...
7.
Thygesen S, Takizawa K, Robertson A, Sester D, Stacey K
Immunol Cell Biol
. 2018 Jul;
97(1):17-28.
PMID: 30052286
Inflammasomes are protein complexes activated by infection and cellular stress that promote caspase-1 activation and subsequent inflammatory cytokine processing and cell death. It has been anticipated that inflammasome activity contributes...
8.
Sester D, Zamoshnikova A, Thygesen S, Vajjhala P, Cridland S, Schroder K, et al.
Curr Protoc Immunol
. 2016 Aug;
114:14.40.1-14.40.29.
PMID: 27479658
Inflammasomes are large protein complexes formed in response to cellular stresses that are platforms for recruitment and activation of caspase 1. Central to most inflammasome functions is the adapter molecule...
9.
Thygesen S, Sester D, Cridland S, Wilton S, Stacey K
Immunol Cell Biol
. 2016 Feb;
94(5):520-4.
PMID: 26833024
Inflammasomes are molecular complexes activated by infection and cellular stress, leading to caspase-1 activation and subsequent interleukin-1β (IL-1β) processing and cell death. The autoimmune NZB mouse strain does not express...
10.
Sester D, Sagulenko V, Thygesen S, Cridland J, Loi Y, Cridland S, et al.
J Immunol
. 2015 Jun;
195(3):1233-41.
PMID: 26116505
Inflammasomes are protein complexes that promote caspase activation, resulting in processing of IL-1β and cell death, in response to infection and cellular stresses. Inflammasomes have been anticipated to contribute to...