Sara B Linker
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Explore the profile of Sara B Linker including associated specialties, affiliations and a list of published articles.
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22
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1202
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Recent Articles
1.
Toda T, Bedrosian T, Schafer S, Cuoco M, Linker S, Ghassemzadeh S, et al.
Cell Rep
. 2024 Feb;
43(2):113774.
PMID: 38349791
Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several...
2.
Parylak S, Qiu F, Linker S, Gallina I, Lim C, Preciado D, et al.
Hippocampus
. 2023 Feb;
33(4):412-423.
PMID: 36811254
Immature dentate granule cells (DGCs) generated in the hippocampus during adulthood are believed to play a unique role in dentate gyrus (DG) function. Although immature DGCs have hyperexcitable membrane properties...
3.
Linker S, Narvaiza I, Hsu J, Wang M, Qiu F, Mendes A, et al.
Curr Biol
. 2022 Oct;
32(22):4797-4807.e5.
PMID: 36228612
Unique aspects of human behavior are often attributed to differences in the relative size and organization of the human brain: these structural aspects originate during early development. Recent studies indicate...
4.
Stern S, Lau S, Manole A, Rosh I, Mendel Percia M, Ben Ezer R, et al.
NPJ Parkinsons Dis
. 2022 Aug;
8(1):103.
PMID: 35948563
Several mutations that cause Parkinson's disease (PD) have been identified over the past decade. These account for 15-25% of PD cases; the rest of the cases are considered sporadic. Currently,...
5.
Gorbunova V, Seluanov A, Mita P, McKerrow W, Fenyo D, Boeke J, et al.
Nature
. 2021 Aug;
596(7870):43-53.
PMID: 34349292
The genomes of virtually all organisms contain repetitive sequences that are generated by the activity of transposable elements (transposons). Transposons are mobile genetic elements that can move from one genomic...
6.
Reid D, Reed P, Schlachetzki J, Nitulescu I, Chou G, Tsui E, et al.
Science
. 2021 Apr;
372(6537):91-94.
PMID: 33795458
Neurons are the longest-lived cells in our bodies and lack DNA replication, which makes them reliant on a limited repertoire of DNA repair mechanisms to maintain genome fidelity. These repair...
7.
Santos R, Linker S, Stern S, Mendes A, Shokhirev M, Erikson G, et al.
Mol Psychiatry
. 2021 Jan;
26(6):2440-2456.
PMID: 33398088
Bipolar disorder (BD) is a psychiatric condition characterized by depressive and manic episodes that affect 2% of the world population. The first-line long-term treatment for mood stabilization is lithium (Li)....
8.
Linker S, Randolph-Moore L, Kottilil K, Qiu F, Jaeger B, Barron J, et al.
Genome Res
. 2020 Oct;
30(11):1643-1654.
PMID: 33122305
Currently, researchers rely on generalized methods to quantify transposable element (TE) RNA expression, such as RT-qPCR and RNA-seq, that do not distinguish between TEs expressed from their own promoter (bona...
9.
Linker S, Mendes A, Marchetto M
Mol Autism
. 2020 Jun;
11(1):55.
PMID: 32591005
Background: Research evidence accumulated in the past years in both rodent and human models for autism spectrum disorders (ASD) have established insulin-like growth factor 1 (IGF-1) as one of the...
10.
Wenderski W, Wang L, Krokhotin A, Walsh J, Li H, Shoji H, et al.
Proc Natl Acad Sci U S A
. 2020 Apr;
117(18):10055-10066.
PMID: 32312822
Synaptic activity in neurons leads to the rapid activation of genes involved in mammalian behavior. ATP-dependent chromatin remodelers such as the BAF complex contribute to these responses and are generally...