Conor Fitzpatrick
Overview
Explore the profile of Conor Fitzpatrick including associated specialties, affiliations and a list of published articles.
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12
Citations
1278
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Recent Articles
1.
Tharp M, Han C, Balak C, Fitzpatrick C, OConnor C, Preissl S, et al.
bioRxiv
. 2024 Jun;
PMID: 38895459
Biological sex is an important risk factor in cancer, but the underlying cell types and mechanisms remain obscure. Since tumor development is regulated by the immune system, we hypothesize that...
2.
Zhou J, Zhang Z, Wu M, Liu H, Pang Y, Bartlett A, et al.
Nature
. 2023 Dec;
624(7991):355-365.
PMID: 38092919
Single-cell analyses parse the brain's billions of neurons into thousands of 'cell-type' clusters residing in different brain structures. Many cell types mediate their functions through targeted long-distance projections allowing interactions...
3.
Zhang Z, Zhou J, Tan P, Pang Y, Rivkin A, Kirchgessner M, et al.
Nature
. 2021 Oct;
598(7879):167-173.
PMID: 34616065
Neuronal cell types are classically defined by their molecular properties, anatomy and functions. Although recent advances in single-cell genomics have led to high-resolution molecular characterization of cell type diversity in...
4.
Liu H, Zhou J, Tian W, Luo C, Bartlett A, Aldridge A, et al.
Nature
. 2021 Oct;
598(7879):120-128.
PMID: 34616061
Mammalian brain cells show remarkable diversity in gene expression, anatomy and function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly understood. Here we carry out a comprehensive...
5.
Lee D, Luo C, Zhou J, Chandran S, Rivkin A, Bartlett A, et al.
Nat Methods
. 2019 Sep;
16(10):999-1006.
PMID: 31501549
Dynamic three-dimensional chromatin conformation is a critical mechanism for gene regulation during development and disease. Despite this, profiling of three-dimensional genome structure from complex tissues with cell-type specific resolution remains...
6.
Luo C, Rivkin A, Zhou J, Sandoval J, Kurihara L, Lucero J, et al.
Nat Commun
. 2018 Sep;
9(1):3824.
PMID: 30237449
Single-cell DNA methylome profiling has enabled the study of epigenomic heterogeneity in complex tissues and during cellular reprogramming. However, broader applications of the method have been impeded by the modest...
7.
Jaeger B, Linker S, Parylak S, Barron J, Gallina I, Saavedra C, et al.
Nat Commun
. 2018 Aug;
9(1):3084.
PMID: 30082781
Activity-induced remodeling of neuronal circuits is critical for memory formation. This process relies in part on transcription, but neither the rate of activity nor baseline transcription is equal across neuronal...
8.
Santos R, Vadodaria K, Jaeger B, Mei A, Lefcochilos-Fogelquist S, Mendes A, et al.
Stem Cell Reports
. 2017 Jun;
8(6):1757-1769.
PMID: 28591655
Astrocyte dysfunction and neuroinflammation are detrimental features in multiple pathologies of the CNS. Therefore, the development of methods that produce functional human astrocytes represents an advance in the study of...
9.
Gosselin D, Skola D, Coufal N, Holtman I, Schlachetzki J, Sajti E, et al.
Science
. 2017 May;
356(6344).
PMID: 28546318
Microglia play essential roles in central nervous system (CNS) homeostasis and influence diverse aspects of neuronal function. However, the transcriptional mechanisms that specify human microglia phenotypes are largely unknown. We...
10.
Lacar B, Linker S, Jaeger B, Krishnaswami S, Barron J, Kelder M, et al.
Nat Commun
. 2017 Mar;
8:15047.
PMID: 28303884
No abstract available.