Sara A M Holec
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Explore the profile of Sara A M Holec including associated specialties, affiliations and a list of published articles.
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10
Citations
119
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Recent Articles
1.
Szegvari E, Holec S, Woerman A
J Neurochem
. 2025 Mar;
169(3):e70021.
PMID: 40026260
Rodent models that accurately recapitulate key aspects of human disease have long been fundamental to the successful development of clinical interventions. This is greatly underscored in the neurodegenerative disease field,...
2.
Holec S, Khedmatgozar C, Schure S, Pham T, Woerman A
PLoS Pathog
. 2024 Dec;
20(12):e1012746.
PMID: 39642110
In patients with synucleinopathies, the protein α-synuclein misfolds into multiple conformations, each of which determines whether a patient develops multiple system atrophy (MSA) or one of three Lewy body diseases...
3.
Reis P, Holec S, Ezeiruaku C, Frost M, Brown C, Liu S, et al.
bioRxiv
. 2024 Jul;
PMID: 39026799
Multiple system atrophy (MSA) and Parkinson's disease (PD) are caused by misfolded -synuclein spreading throughout the central nervous system. While familial PD is linked to several point mutations in -synuclein,...
4.
Khedmatgozar C, Holec S, Woerman A
PLoS Pathog
. 2024 Jan;
20(1):e1011920.
PMID: 38271292
No abstract available.
5.
Holec S, Lee J, Oehler A, Batia L, Wiggins-Gamble A, Lau J, et al.
PLoS Pathog
. 2022 Dec;
18(12):e1010956.
PMID: 36454879
In multiple system atrophy (MSA), the α-synuclein protein misfolds into a self-templating prion conformation that spreads throughout the brain, leading to progressive neurodegeneration. While the E46K mutation in α-synuclein causes...
6.
Holec S, Lee J, Oehler A, Ooi F, Mordes D, Olson S, et al.
Acta Neuropathol
. 2022 Aug;
144(4):677-690.
PMID: 36018376
In multiple system atrophy (MSA), the protein α-synuclein misfolds into a prion conformation that self-templates and causes progressive neurodegeneration. While many point mutations in the α-synuclein gene, SNCA, have been...
7.
Holec S, Liu S, Woerman A
Acta Neuropathol
. 2022 Feb;
143(3):311-330.
PMID: 35122113
Synucleinopathies are a group of clinically and neuropathologically distinct protein misfolding diseases caused by unique α-synuclein conformations, or strains. While multiple atomic resolution cryo-electron microscopy structures of α-synuclein fibrils are...
8.
Holec S, Block A, Bartz J
Prog Mol Biol Transl Sci
. 2020 Sep;
175:77-119.
PMID: 32958242
Prions are a self-propagating misfolded conformation of a cellular protein. Prions are found in several eukaryotic organisms with mammalian prion diseases encompassing a wide range of disorders. The first recognized...
9.
Holec S, Woerman A
Acta Neuropathol
. 2020 May;
142(1):73-86.
PMID: 32440702
Synucleinopathies are a group of neurodegenerative disorders caused by the misfolding and self-templating of the protein α-synuclein, or the formation of α-synuclein prions. Each disorder differs by age of onset,...
10.
Holec S, Yuan Q, Bartz J
mSphere
. 2019 Oct;
4(5).
PMID: 31597719
Prions can persist in the environment for extended periods of time after adsorption to surfaces, including soils, feeding troughs, or fences. Prion strain- and soil-specific differences in prion adsorption, infectivity,...