Santosh R Rananaware
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Explore the profile of Santosh R Rananaware including associated specialties, affiliations and a list of published articles.
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13
Citations
61
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Recent Articles
1.
Orosco C, Rananaware S, Huang B, Hanna M, Ahmadimashhadi M, Lewis J, et al.
medRxiv
. 2024 Nov;
PMID: 39606390
CRISPR-Cas nucleases are transforming genome editing, RNA editing, and diagnostics but have been limited to RNA-guided systems. We present ΨDNA, a DNA-based guide for Cas12 enzymes, engineered for specific and...
2.
Jia Y, Horvath K, Rananaware S, Jain P, Sampath J
ArXiv
. 2024 Sep;
PMID: 39253640
CRISPR (clustered regularly interspaced short palindromic repeat)-based diagnostics are at the forefront of rapid detection platforms of infectious diseases. The integration of reverse transcription-loop-mediated isothermal amplification (RT-LAMP) with CRISPR-Cas protein...
3.
Rananaware S, Meister K, Shoemaker G, Vesco E, Sandoval L, Lewis J, et al.
medRxiv
. 2024 May;
PMID: 38746294
Type V CRISPR-Cas effectors have revolutionized molecular diagnostics by facilitating the detection of nucleic acid biomarkers. However, their dependence on the presence of protospacer adjacent motif (PAM) sites on the...
4.
Nguyen L, Macaluso N, Rakestraw N, Carman D, Pizzano B, Hautamaki R, et al.
Cell Rep
. 2024 Feb;
43(2):113777.
PMID: 38358883
There is a broad diversity among Cas12a endonucleases that possess nucleic acid detection and gene-editing capabilities, but few are studied extensively. Here, we present an exhaustive investigation of 23 Cas12a...
5.
Shashank P, Parker B, Rananaware S, Plotkin D, Couch C, Yang L, et al.
Mol Ecol Resour
. 2023 Oct;
24(1):e13881.
PMID: 37888995
Rapid identification of organisms is essential for many biological and medical disciplines, from understanding basic ecosystem processes, disease diagnosis, to the detection of invasive pests. CRISPR-based diagnostics offers a novel...
6.
Rananaware S, Vesco E, Shoemaker G, Anekar S, Sandoval L, Meister K, et al.
Nat Commun
. 2023 Sep;
14(1):5409.
PMID: 37669948
Cas12a, a CRISPR-associated protein complex, has an inherent ability to cleave DNA substrates and is utilized in diagnostic tools to identify DNA molecules. We demonstrate that multiple orthologs of Cas12a...
7.
Shashank P, Parker B, Rananaware S, Plotkin D, Couch C, Yang L, et al.
bioRxiv
. 2023 Jun;
PMID: 37292907
Rapid identification of organisms is essential across many biological and medical disciplines, from understanding basic ecosystem processes and how organisms respond to environmental change, to disease diagnosis and detection of...
8.
Nguyen L, Rananaware S, Yang L, Macaluso N, Ocana-Ortiz J, Meister K, et al.
Cell Rep Med
. 2023 May;
4(5):101037.
PMID: 37160120
CRISPR-Cas-based diagnostics have the potential to elevate nucleic acid detection. CRISPR-Cas systems can be combined with a pre-amplification step in a one-pot reaction to simplify the workflow and reduce carryover...
9.
Rananaware S, Vesco E, Shoemaker G, Anekar S, Sandoval L, Meister K, et al.
Res Sq
. 2023 Feb;
PMID: 36824842
CRISPR is a prominent bioengineering tool and the type V CRISPR-associated protein complex, Cas12a, is widely used in diagnostic platforms due to its innate ability to cleave DNA substrates. Here...
10.
Rananaware S, Vesco E, Shoemaker G, Anekar S, Sandoval L, Meister K, et al.
bioRxiv
. 2023 Feb;
PMID: 36778248
Abstract Figure: