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Sanjay Chandriani

Explore the profile of Sanjay Chandriani including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 988
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Recent Articles
1.
Babcock M, Mikulka C, Wang B, Chandriani S, Chandra S, Xu Y, et al.
Sci Rep . 2021 Jul; 11(1):14486. PMID: 34262084
Krabbe disease (KD) and metachromatic leukodystrophy (MLD) are caused by accumulation of the glycolipids galactosylceramide (GalCer) and sulfatide and their toxic metabolites psychosine and lysosulfatide, respectively. We discovered a potent...
2.
Ru Y, Corado C, Soon Jr R, Melton A, Harris A, Yu G, et al.
Ann Clin Transl Neurol . 2019 Dec; 6(12):2437-2447. PMID: 31814335
Objective: Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is a rare, progressive, fatal neurodegenerative pediatric disorder resulting from deficiencies of the lysosomal enzyme tripeptidyl peptidase 1 that are caused by...
3.
Lawrence R, Van Vleet J, Mangini L, Harris A, Martin N, Clark W, et al.
Mol Genet Metab Rep . 2019 Nov; 21:100524. PMID: 31720227
Introduction: GM1 gangliosidosis is a rare autosomal recessive genetic disorder caused by the disruption of the gene that encodes β-galactosidase, a lysosomal hydrolase that removes β-linked galactose from the non-reducing...
4.
Jia G, Chandriani S, Abbas A, DePianto D, NDiaye E, Yaylaoglu M, et al.
Thorax . 2017 Mar; 72(9):780-787. PMID: 28250200
Background: Idiopathic pulmonary fibrosis (IPF) is associated with aberrant expression of developmental pathways, including Hedgehog (Hh). As Hh signalling contributes to multiple pro-fibrotic processes, Hh inhibition may represent a therapeutic...
5.
DePianto D, Chandriani S, Abbas A, Jia G, NDiaye E, Caplazi P, et al.
Thorax . 2014 Sep; 70(1):48-56. PMID: 25217476
Background: There is microscopic spatial and temporal heterogeneity of pathological changes in idiopathic pulmonary fibrosis (IPF) lung tissue, which may relate to heterogeneity in pathophysiological mediators of disease and clinical...
6.
Chandriani S, DePianto D, NDiaye E, Abbas A, Jackman J, Bevers 3rd J, et al.
J Immunol . 2014 Jun; 193(1):111-9. PMID: 24879793
IL-13 can bind to two distinct receptors: a heterodimer of IL-13Rα1/IL-4Rα and IL-13Rα2. Whereas IL-13Rα1/IL-4Rα engagement by IL-13 leads to the activation of STAT6, the molecular events triggered by IL-13...
7.
Chandriani S, Skewes-Cox P, Zhong W, Ganem D, Divers T, Van Blaricum A, et al.
Proc Natl Acad Sci U S A . 2013 Mar; 110(15):E1407-15. PMID: 23509292
Theiler's disease is an acute hepatitis in horses that is associated with the administration of equine blood products; its etiologic agent has remained unknown for nearly a century. Here, we...
8.
Horiuchi D, Kusdra L, Huskey N, Chandriani S, Lenburg M, Gonzalez-Angulo A, et al.
J Exp Med . 2012 Mar; 209(4):679-96. PMID: 22430491
Estrogen, progesterone, and HER2 receptor-negative triple-negative breast cancers encompass the most clinically challenging subtype for which targeted therapeutics are lacking. We find that triple-negative tumors exhibit elevated MYC expression, as...
9.
Chandriani S, Xu Y, Ganem D
J Virol . 2010 Jun; 84(16):7934-42. PMID: 20534856
Genomewide analyses of the mammalian transcriptome have revealed that large tracts of sequence previously annotated as noncoding are frequently transcribed and give rise to stable RNA. Although the transcription of...
10.
Chandriani S, Ganem D
J Virol . 2010 Mar; 84(11):5565-73. PMID: 20219929
Kaposi's sarcoma-associated herpesvirus (KSHV) is a B-lymphotropic herpesvirus strongly linked to both lymphoproliferative diseases and Kaposi's sarcoma. The viral latency program of KSHV is central to persistent infection and plays...