Sanja Pajovic
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Explore the profile of Sanja Pajovic including associated specialties, affiliations and a list of published articles.
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20
Citations
1047
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Recent Articles
1.
Anguraj Vadivel A, Pajovic S, Siddaway R, Zhu S, Sbergio S, Matic O, et al.
Neuro Oncol
. 2025 Feb;
PMID: 39954016
Background: Diffuse Midline Glioma (DMG) is a highly aggressive pediatric brain tumor with limited treatment options despite extensive genomic characterization. The aim of this study was to investigate the proteomic...
2.
Siddaway R, Milos S, Coyaud E, Yun H, Morcos S, Pajovic S, et al.
Mol Cell Proteomics
. 2022 Sep;
21(10):100411.
PMID: 36089195
Chromatin structure, transcription, DNA replication, and repair are regulated via locus-specific incorporation of histone variants and posttranslational modifications that guide effector chromatin-binding proteins. Here we report unbiased, quantitative interactomes for...
3.
Siddaway R, Canty L, Pajovic S, Milos S, Coyaud E, Sbergio S, et al.
Acta Neuropathol
. 2022 Sep;
144(5):1027-1048.
PMID: 36070144
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negative...
4.
Siddaway R, Milos S, Anguraj Vadivel A, Dobson T, Swaminathan J, Ryall S, et al.
Nat Commun
. 2022 Feb;
13(1):588.
PMID: 35102191
High-grade diffuse glioma (HGG) is the leading cause of brain tumour death. While the genetic drivers of HGG have been well described, targeting these has thus far had little impact...
5.
Pajovic S, Siddaway R, Bridge T, Sheth J, Rakopoulos P, Kim B, et al.
Nat Commun
. 2020 Dec;
11(1):6216.
PMID: 33277484
Histone H3 lysine 27 (H3K27M) mutations represent the canonical oncohistone, occurring frequently in midline gliomas but also identified in haematopoietic malignancies and carcinomas. H3K27M functions, at least in part, through...
6.
Ryall S, Zapotocky M, Fukuoka K, Nobre L, Stucklin A, Bennett J, et al.
Cancer Cell
. 2020 Apr;
37(4):569-583.e5.
PMID: 32289278
Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in their clinical outcome. To address this, we characterized...
7.
Ryall S, Krishnatry R, Arnoldo A, Buczkowicz P, Mistry M, Siddaway R, et al.
Acta Neuropathol Commun
. 2016 Sep;
4(1):93.
PMID: 27577993
Paediatric brain tumours arising in the thalamus present significant diagnostic and therapeutic challenges to physicians due to their sensitive midline location. As such, genetic analysis for biomarkers to aid in...
8.
Barszczyk M, Buczkowicz P, Castelo-Branco P, Mack S, Ramaswamy V, Mangerel J, et al.
Acta Neuropathol
. 2014 Aug;
128(6):863-77.
PMID: 25120190
Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating...
9.
Agnihotri S, Burrell K, Buczkowicz P, Remke M, Golbourn B, Chornenkyy Y, et al.
Cancer Discov
. 2014 Aug;
4(10):1198-213.
PMID: 25100205
Unlabelled: Alkylating agents are a first-line therapy for the treatment of several aggressive cancers, including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy....
10.
Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M, et al.
Nat Genet
. 2014 Apr;
46(5):451-6.
PMID: 24705254
Diffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children, with no effective treatment and near 100% fatality. The failure of most therapies...