Sangaralingam Kumaran
Overview
Explore the profile of Sangaralingam Kumaran including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
257
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0
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Recent Articles
1.
Pandya V, Shankar S, Sonwane B, Rajesh S, Rathore R, Kumaran S, et al.
Biochim Biophys Acta Gen Subj
. 2022 Dec;
1867(3):130290.
PMID: 36529243
Anserine and carnosine represent histidine-containing dipeptides that exert a pluripotent protective effect on human physiology. Anserine is known to protect against oxidative stress in diabetes and cardiovascular diseases. Human carnosinases...
2.
Pandya V, Sonwane B, Rathore R, Unnikrishnan A, Kumaran S, Kulkarni M
RSC Adv
. 2022 May;
10(2):763-769.
PMID: 35494477
Carnosine, a histidine containing dipeptide, exerts beneficial effects by scavenging reactive carbonyl compounds (RCCs) that are implicated in pathogenesis of diabetes. However, the reduced carnosine levels may aggravate the severity...
3.
Kaushik A, Ekka M, Kumaran S
Biochemistry
. 2017 Apr;
56(18):2385-2399.
PMID: 28414426
Serine acetyltransferase (SAT) and O-acetylserine sulfhydrylase (OASS), which catalyze the last two steps of cysteine biosynthesis, interact and form the cysteine regulatory complex (CRC). The current model of Salmonella typhimurium...
4.
Yi H, Dey S, Kumaran S, Lee S, Krishnan H, Jez J
J Biol Chem
. 2013 Nov;
288(51):36463-72.
PMID: 24225955
Serine acetyltransferase (SAT) catalyzes the limiting reaction in plant and microbial biosynthesis of cysteine. In addition to its enzymatic function, SAT forms a macromolecular complex with O-acetylserine sulfhydrylase. Formation of...
5.
Anand S, Singh V, Singh A, Mittal M, Datt M, Subramani B, et al.
FEBS J
. 2012 Jul;
279(17):3214-28.
PMID: 22805491
Fatty acids play critical role in the survival and virulence of Mycobacterium tuberculosis (Mtb). Activation of fatty acids by acyl-CoA synthetases (Fad) into fatty acyl-CoA is the first and one...
6.
Singh V, Ekka M, Kumaran S
Biochemistry
. 2012 Jan;
51(7):1346-56.
PMID: 22268791
PhoP, the response regulator of the PhoP/PhoQ system, regulates Mg(2+) homeostasis in Salmonella typhimurium. Dimerization of PhoP on the DNA is necessary for its regulatory function, and PhoP regulates the...
7.
Kanudia P, Mittal M, Kumaran S, Chakraborti P
BMC Biochem
. 2011 Jul;
12:35.
PMID: 21729287
Background: Methionine aminopeptidase (MetAP) is a ubiquitous enzyme in both prokaryotes and eukaryotes, which catalyzes co-translational removal of N-terminal methionine from elongating polypeptide chains during protein synthesis. It specifically removes...
8.
Banerjee S, Ekka M, Kumaran S
BMC Biochem
. 2011 Jun;
12:31.
PMID: 21631959
Background: The importance of understanding the detailed mechanism of cysteine biosynthesis in bacteria is underscored by the fact that cysteine is the only sulfur donor for all cellular components containing...
9.
Kaur H, Datt M, Ekka M, Mittal M, Singh A, Kumaran S
Biochimie
. 2010 Sep;
93(2):175-86.
PMID: 20868722
Dug1p is a recently identified novel dipeptidase and plays an important role in glutathione (GSH) degradation. To understand the mechanism of its substrate recognition and specificity towards Cys-Gly dipeptides, we...
10.
Kumaran S, Yi H, Krishnan H, Jez J
J Biol Chem
. 2009 Feb;
284(15):10268-75.
PMID: 19213732
Macromolecular assemblies play critical roles in regulating cellular functions. The cysteine synthase complex (CSC), which is formed by association of serine O-acetyltransferase (SAT) and O-acetylserine sulfhydrylase (OASS), acts as a...