Sangam Rajak
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Explore the profile of Sangam Rajak including associated specialties, affiliations and a list of published articles.
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29
Citations
322
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Recent Articles
1.
Rajak S, Shah A, Yadav A, Shahi A, Raza S, Singh M, et al.
Biochem Biophys Res Commun
. 2024 Dec;
743:151171.
PMID: 39693938
Lipotoxicity is a key pathological feature in the development of non-alcoholic steatohepatitis (NASH), which is characterized by liver injury, inflammation, and fibrosis. Although lipotoxicity has been shown to induce transcriptomic...
2.
Liver-specific thyroid hormone receptor-β agonism alleviates alcoholic steatohepatitis (ASH) in mice
Shahi A, Yadav A, Rajak S, Raza S, Tewari A, Gupta P, et al.
Biochem Biophys Res Commun
. 2024 Oct;
734:150742.
PMID: 39353359
Alcoholic steatohepatitis (ASH) represents a critical stage in alcoholic liver disease (ALD), which significantly increases the risk of developing alcoholic hepatitis and cirrhosis. Currently, corticosteroids and alcohol abstinence remain the...
3.
Raza S, Rajak S, Yen P, Sinha R
NPJ Metab Health Dis
. 2024 Aug;
2(1):19.
PMID: 39100919
Metabolic dysfunction-associated steatotic liver disease (MASLD) originates from a homeostatic imbalance in hepatic lipid metabolism. Increased fat deposition in the liver of people suffering from MASLD predisposes them to develop...
4.
Uzair M, Singhal C, Ali A, Rajak S, Kapoor A, Agarwal S, et al.
Thromb Res
. 2024 May;
238:117-128.
PMID: 38703585
Previous research has identified intravascular platelet thrombi in regions affected by myocardial ischemia-reperfusion (MI/R) injury and neighbouring areas. However, the occurrence of arterial thrombosis in the context of MI/R injury...
5.
Rajak S
Biochim Biophys Acta Mol Basis Dis
. 2024 Feb;
1870(4):167102.
PMID: 38422712
Non-alcoholic steatohepatitis (NASH) is a pathogenic stage of the broader non-alcoholic fatty liver disease (NAFLD). Histological presentation of NASH includes hepatocyte ballooning, macrophage polarization, ductular reaction, and hepatic stellate cell...
6.
Raza S, Rajak S, Singh R, Zhou J, Sinha R, Goel A
World J Hepatol
. 2024 Jan;
15(12):1272-1283.
PMID: 38192406
Autophagy, a cellular degradative process, has emerged as a key regulator of cellular energy production and stress mitigation. Dysregulated autophagy is a common phenomenon observed in several human diseases, and...
7.
Raza S, Shahi A, Medhe P, Tewari A, Gupta P, Rajak S, et al.
Biochim Biophys Acta Mol Cell Res
. 2023 Sep;
1871(1):119597.
PMID: 37741573
Dietary fructose intake through increased consumption of refined sugar induces hepatic de novo lipogenesis (DNL), a major contributor to hepatic steatosis in NAFLD, however, it's mechanism is not completely understood....
8.
Tewari A, Rajak S, Raza S, Gupta P, Chakravarti B, Srivastava J, et al.
Cells
. 2023 Jul;
12(14):1845.
PMID: 37484201
Non-alcoholic steatohepatitis (NASH) is a clinically serious stage of non-alcoholic fatty liver disease (NAFLD). Histologically characterized by hepatocyte ballooning, immune cell infiltration, and fibrosis, NASH, at a molecular level, involves...
9.
Rajak S, Tewari A, Raza S, Gupta P, Chakravarti B, Anjum B, et al.
Biochim Biophys Acta Mol Basis Dis
. 2023 Feb;
1869(4):166662.
PMID: 36754244
Nonalcoholic steatohepatitis (NASH) is considered a pivotal stage in nonalcoholic fatty liver disease (NAFLD) progression and increases the risk of end-stage liver diseases such as fibrosis, cirrhosis, and hepatocellular carcinoma...
10.
Hussain Y, Singh J, Raza W, Meena A, Rajak S, Sinha R, et al.
Life Sci
. 2022 Sep;
309:120964.
PMID: 36115584
Introduction And Aim: Purpurin, a naturally occurring anthraquinone isolated from the roots of Rubia cordifolia, exhibits anti-cancer, anti-genotoxic, anti-microbial, neuromodulatory and photodynamic activity. However, purpurin's in vivo and in vitro...