Rohit A Sinha
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Explore the profile of Rohit A Sinha including associated specialties, affiliations and a list of published articles.
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67
Citations
1824
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Recent Articles
1.
Rajak S, Shah A, Yadav A, Shahi A, Raza S, Singh M, et al.
Biochem Biophys Res Commun
. 2024 Dec;
743:151171.
PMID: 39693938
Lipotoxicity is a key pathological feature in the development of non-alcoholic steatohepatitis (NASH), which is characterized by liver injury, inflammation, and fibrosis. Although lipotoxicity has been shown to induce transcriptomic...
2.
Singh A, Anjum B, Naz Q, Raza S, Sinha R, Ahmad M, et al.
Hepatoma Res
. 2024 Nov;
PMID: 39525867
The circadian system plays a crucial role in regulating metabolic homeostasis at both systemic and tissue levels by synchronizing the central and peripheral clocks with exogenous time cues, known as...
3.
Sinha R, Bruinstroop E, Yen P
Nat Rev Gastroenterol Hepatol
. 2024 Oct;
22(1):9-22.
PMID: 39420154
Thyroid hormones (triiodothyronine and thyroxine) are pivotal for metabolic balance in the liver and entire body. Dysregulation of the hypothalamus-pituitary-thyroid axis can contribute to hepatic metabolic disturbances, affecting lipid metabolism,...
4.
Sinha R
Endocrinol Metab (Seoul)
. 2024 Oct;
39(5):686-692.
PMID: 39397515
The influence of thyroid hormone (TH) on liver metabolism has attracted the attention of pharmacologists seeking new treatments for metabolic dysfunction-associated steatotic liver disease (MASLD), an increasingly common metabolic disorder....
5.
Liver-specific thyroid hormone receptor-β agonism alleviates alcoholic steatohepatitis (ASH) in mice
Shahi A, Yadav A, Rajak S, Raza S, Tewari A, Gupta P, et al.
Biochem Biophys Res Commun
. 2024 Oct;
734:150742.
PMID: 39353359
Alcoholic steatohepatitis (ASH) represents a critical stage in alcoholic liver disease (ALD), which significantly increases the risk of developing alcoholic hepatitis and cirrhosis. Currently, corticosteroids and alcohol abstinence remain the...
6.
Raza S, Rajak S, Yen P, Sinha R
NPJ Metab Health Dis
. 2024 Aug;
2(1):19.
PMID: 39100919
Metabolic dysfunction-associated steatotic liver disease (MASLD) originates from a homeostatic imbalance in hepatic lipid metabolism. Increased fat deposition in the liver of people suffering from MASLD predisposes them to develop...
7.
Japanese encephalitis virus infection causes reactive oxygen species-mediated skeletal muscle damage
Singh G, Singh K, Sinha R, Singh A, Khushi , Kumar A
Eur J Neurosci
. 2024 Jul;
60(5):4843-4860.
PMID: 39049535
Skeletal muscle wasting is a clinically proven pathology associated with Japanese encephalitis virus (JEV) infection; however, underlying factors that govern skeletal muscle damage are yet to be explored. The current...
8.
Sinha R, Yen P
Nat Metab
. 2024 Apr;
6(4):639-650.
PMID: 38671149
Thyroid hormones (THs) are key hormones that regulate development and metabolism in mammals. In man, the major target tissues for TH action are the brain, liver, muscle, heart, and adipose...
9.
Sinha R
Liver Res
. 2024 Mar;
8(1):34-45.
PMID: 38544909
The onset of metabolic dysfunction-associated steatohepatitis (MASH) or non-alcoholic steatohepatitis (NASH) represents a tipping point leading to liver injury and subsequent hepatic complications in the natural progression of what is...
10.
Raza S, Rajak S, Singh R, Zhou J, Sinha R, Goel A
World J Hepatol
. 2024 Jan;
15(12):1272-1283.
PMID: 38192406
Autophagy, a cellular degradative process, has emerged as a key regulator of cellular energy production and stress mitigation. Dysregulated autophagy is a common phenomenon observed in several human diseases, and...