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Sandro Altamura

Explore the profile of Sandro Altamura including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 66
Citations 1896
Followers 0
Related Specialties
Hematology
Biochemistry
Cell Biology
Top 10 Co-Authors
Martina U Muckenthaler
Silvia Colucci
Oriana Marques
Matthias W Hentze
Katja Mudder
Guidalberto Manfioletti
Martina Rauner
Lorenz C Hofbauer
Bruno Galy
Vincenzo Giancotti
Published In
Blood
Haematologica
Hemasphere
Nat Metab
J Biol Chem
Affiliations
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Recent Articles
1.
Inflammation-driven NF-κB signaling represses ferroportin transcription in macrophages via HDAC1 and HDAC3
Marques O, Horvat N, Zechner L, Colucci S, Sparla R, Zimmermann S, et al.
Blood . 2024 Dec; 145(8):866-880. PMID: 39656097
Anemia of inflammation is a prevalent comorbidity in patients with chronic inflammatory disorders. Inflammation causes hypoferremia and iron-restricted erythropoiesis by limiting ferroportin (FPN)-mediated iron export from macrophages that recycle senescent...
2.
Depletion of macrophages and osteoclast precursors mitigates iron overload-mediated bone loss
Passin V, Ledesma-Colunga M, Altamura S, Muckenthaler M, Baschant U, Hofbauer L, et al.
IUBMB Life . 2024 Nov; 77(1):e2928. PMID: 39555707
Iron is an essential element for physiological cellular processes, but is toxic in excess. Iron overload diseases are commonly associated with low bone mass. Increased bone resorption by osteoclasts as...
3.
Knock-out of dipeptidase CN2 in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para- and transcellular solute transport
Pfeffer T, Krug S, Kracke T, Schurfeld R, Colbatzky F, Kirschner P, et al.
Acta Physiol (Oxf) . 2024 Mar; 240(4):e14126. PMID: 38517248
Aim: Although of potential biomedical relevance, dipeptide metabolism has hardly been studied. We found the dipeptidase carnosinase-2 (CN2) to be abundant in human proximal tubules, which regulate water and solute...
4.
A functional interplay between the two BMP-SMAD pathway inhibitors TMPRSS6 and FKBP12 regulates expression in vivo
Pettinato M, Aghajan M, Guo S, Bavuso Volpe L, Carleo R, Nai A, et al.
Am J Physiol Gastrointest Liver Physiol . 2024 Jan; 326(3):G310-G317. PMID: 38252872
The Activin A Receptor type I (ALK2) is a critical component of BMP-SMAD signaling that, in the presence of ligands, phosphorylates cytosolic SMAD1/5/8 and modulates important biological processes, including bone...
5.
Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1α activation
Klement L, Jansakun C, Yan B, Staffer S, Tuma-Kellner S, Altamura S, et al.
Biochim Biophys Acta Mol Basis Dis . 2024 Jan; 1870(3):167016. PMID: 38198970
Polymorphisms of group VIA calcium-independent phospholipase A2 (PLA2G6) are associated with blood C-reactive protein suggesting its role in inflammation. We showed that myeloid-specific Pla2g6-deficiency in Pla2g6 mice led to exaggerated...
6.
Myeloid-specific fatty acid transport protein 4 deficiency induces a sex-dimorphic susceptibility for nonalcoholic steatohepatitis in mice fed a high-fat, high-cholesterol diet
Gocebe D, Jansakun C, Zhang Y, Staffer S, Tuma-Kellner S, Altamura S, et al.
Am J Physiol Gastrointest Liver Physiol . 2023 Mar; 324(5):G389-G403. PMID: 36881564
Newborns with FATP4 mutations exhibit ichthyosis prematurity syndrome (IPS), and adult patients show skin hyperkeratosis, allergies, and eosinophilia. We have previously shown that the polarization of macrophages is altered by...
7.
T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles
Turco V, Pfleiderer K, Hunger J, Horvat N, Karimian-Jazi K, Schregel K, et al.
Nat Commun . 2023 Feb; 14(1):771. PMID: 36774352
Glioblastoma, the most common and aggressive primary brain tumor type, is considered an immunologically "cold" tumor with sparse infiltration by adaptive immune cells. Immunosuppressive tumor-associated myeloid cells are drivers of...
8.
Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes
Qiu R, Alikhanyan K, Volk N, Marques O, Mertens C, Ruban Agarvas A, et al.
Mol Metab . 2022 Nov; 66:101644. PMID: 36436807
Objective: Hyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM). Likewise, patients with genetic iron overload diseases develop diabetes, suggesting a tight link...
9.
Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH
Jansakun C, Chunglok W, Altamura S, Muckenthaler M, Staffer S, Tuma-Kellner S, et al.
Biochim Biophys Acta Mol Basis Dis . 2022 Nov; 1869(1):166590. PMID: 36334837
Polymorphisms of phospholipase A2VIA (iPLA2β or PLA2G6) are associated with body weights and blood C-reactive protein. The role of iPLA2β/PLA2G6 in non-alcoholic steatohepatitis (NASH) is still elusive because female iPla2β-null...
10.
Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow
Bonadonna M, Altamura S, Tybl E, Palais G, Qatato M, Polycarpou-Schwarz M, et al.
Sci Adv . 2022 Oct; 8(40):eabq4469. PMID: 36197975
Iron is mostly devoted to the hemoglobinization of erythrocytes for oxygen transport. However, emerging evidence points to a broader role for the metal in hematopoiesis, including the formation of the...