Sandra Larkin
Overview
Explore the profile of Sandra Larkin including associated specialties, affiliations and a list of published articles.
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18
Citations
321
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Recent Articles
11.
Morris C, Kim H, Wood J, Porter J, Klings E, Trachtenberg F, et al.
Haematologica
. 2013 Apr;
98(9):1359-67.
PMID: 23585527
Pulmonary hypertension is a common but often overlooked complication associated with thalassemia syndromes. There are limited data on the safety and efficacy of selective pulmonary vasodilators in this at-risk population....
12.
Smith S, Witkowski A, Moghul A, Yoshinaga Y, Nefedov M, de Jong P, et al.
PLoS One
. 2012 Oct;
7(10):e47196.
PMID: 23077570
A mouse model with compromised mitochondrial fatty acid synthesis has been engineered in order to assess the role of this pathway in mitochondrial function and overall health. Reduction in the...
13.
Hoppe C, Kuypers F, Larkin S, Hagar W, Vichinsky E, Styles L
Br J Haematol
. 2011 Apr;
153(5):655-63.
PMID: 21477202
Sickle cell disease (SCD) is characterized by progressive vascular injury and its pathophysiology is strikingly similar to that of atherosclerosis. Statins decrease inflammation and improve endothelial function in cardiovascular disease,...
14.
Serikov V, Hounshell C, Larkin S, Green W, Ikeda H, Walters M, et al.
Exp Biol Med (Maywood)
. 2009 May;
234(7):813-23.
PMID: 19429852
The main barrier to a broader clinical application of umbilical cord blood (UCB) transplantation is its limiting cellular content. Thus, the discovery of hematopoietic progenitor cells in murine placental tissue...
15.
Singer S, Vichinsky E, Larkin S, Olivieri N, Sweeters N, Kuypers F
Am J Hematol
. 2008 Sep;
83(11):842-5.
PMID: 18821710
In thalassemia, fetal hemoglobin (HbF) augmentation with hydroxycarbamide (also known as hydroxyurea) is not always successful. The expected parallel effects on red cell (RBC) membrane deformability, cell hydration, and membrane...
16.
Morris C, Suh J, Hagar W, Larkin S, Bland D, Steinberg M, et al.
Blood
. 2007 Sep;
111(1):402-10.
PMID: 17848621
Erythrocyte glutathione depletion has been linked to hemolysis and oxidative stress. Glutamine plays an additional antioxidant role through preservation of intracellular nicotinamide adenine dinucleotide phosphate (NADPH) levels, required for glutathione...
17.
Styles L, Abboud M, Larkin S, Lo M, Kuypers F
Br J Haematol
. 2006 Dec;
136(2):343-4.
PMID: 17156397
Acute pulmonary injury is known as acute chest syndrome (ACS) in patients with sickle cell disease (SCD). Secretory phospholipase A2 (sPLA2) was found to predict those at risk for ACS...
18.
Morris C, Kuypers F, Kato G, Lavrisha L, Larkin S, Singer T, et al.
Ann N Y Acad Sci
. 2005 Dec;
1054:481-5.
PMID: 16339702
Accumulating evidence supports the existence of a condition involving hemolysis-associated pulmonary hypertension (PHT). Hemolysis-induced release of cell-free hemoglobin and red blood cell arginase, resulting in impaired nitric oxide bioavailability, endothelial...