Sandra Halwachs
Overview
Explore the profile of Sandra Halwachs including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
67
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Recent Articles
1.
Kuhnert L, Giantin M, Dacasto M, Halwachs S, Honscha W
PLoS One
. 2020 Aug;
15(8):e0237163.
PMID: 32764792
In bovine mammary glands, the ABCG2 transporter actively secretes xenobiotics into dairy milk. This can have significant implications when cattle are exposed to pesticide residues in feed. Recent studies indicate...
2.
Halwachs S, Schafer I, Kneuer C, Seibel P, Honscha W
Toxicol Appl Pharmacol
. 2016 Jun;
305:66-74.
PMID: 27288731
In humans, the ATP-binding cassette efflux transporter ABCG2 contributes to the fetoprotective barrier function of the placenta, potentially limiting the toxicity of transporter substrates to the fetus. During testing of...
3.
Mahnke H, Ballent M, Baumann S, Imperiale F, von Bergen M, Lanusse C, et al.
Drug Metab Dispos
. 2016 Mar;
44(5):700-8.
PMID: 26956640
In human and mice ATP-binding cassette efflux transporter ABCG2 represents the main route for active drug transport into milk. However, there is no detailed information on the role of ABCG2...
4.
Halwachs S, Kneuer C, Gohlsch K, Muller M, Ritz V, Honscha W
Placenta
. 2016 Feb;
38:8-15.
PMID: 26907376
In human placenta, the ATP-binding cassette efflux transporter ABCG2 is highly expressed in syncytiotrophoblast cells and mediates cellular excretion of various drugs and toxins. Hence, physiological ABCG2 activity substantially contributes...
5.
Halwachs S, Wassermann L, Honscha W
Toxicol In Vitro
. 2014 Jan;
28(3):432-41.
PMID: 24389113
The ABC efflux transporter ABCG2 represents the main route for active secretion of xenobiotics into milk. Thus, ABCG2 regulation by aryl hydrocarbon receptor (AhR) ligands including ubiquitously environmental pollutants is...
6.
Halwachs S, Lakoma C, Honscha W
Altern Lab Anim
. 2013 Dec;
41(5):369-83.
PMID: 24329745
In a pilot study, we tested 20 randomly-selected chemicals for their cytotoxicity toward the HPCT-1E3 cell model, in order to prove the ability of this in vitro model to predict...
7.
Wassermann L, Halwachs S, Baumann D, Schaefer I, Seibel P, Honscha W
Arch Toxicol
. 2013 Sep;
87(10):1865-7.
PMID: 24043267
No abstract available.
8.
Wassermann L, Halwachs S, Baumann D, Schaefer I, Seibel P, Honscha W
Arch Toxicol
. 2013 May;
87(9):1671-82.
PMID: 23652544
The ATP-binding cassette (ABC) efflux transporter ABCG2 represents the main route for active secretion of drugs and toxins across the blood-milk barrier, thereby producing a potential health risk for dairy...
9.
Wassermann L, Halwachs S, Lindner S, Honscha K, Honscha W
J Pharm Sci
. 2012 Nov;
102(2):772-84.
PMID: 23192864
The ATP-binding cassette subfamily G member 2 (ABCG2) transporter is a member of the ATP-binding cassette (ABC) family of efflux carriers that mediates cellular extrusion of various drugs and toxins....
10.
Halwachs S, Wassermann L, Lindner S, Zizzadoro C, Honscha W
Toxicol Sci
. 2012 Oct;
131(2):491-501.
PMID: 23081912
The molecular mechanisms by which environmental pollutants including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or widely used imidazole fungicide prochloraz display their toxic effects in vertebrates are still not well understood. Using computer analysis,...