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Sandra Halwachs

Explore the profile of Sandra Halwachs including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 15
Citations 67
Followers 0
Related Specialties
Pharmacology
Toxicology
General Medicine
Top 10 Co-Authors
Walther Honscha
Peter Seibel
Louise Wassermann
Carsten Kneuer
Ingo Schaefer
Ingo Schafer
Cathleen Lakoma
Daniela Baumann
Stefan Lindner
Adrian L Lifschitz
Published In
Arch Toxicol
Toxicol Appl Pharmacol
Eur J Cell Biol
Mol Pharmacol
J Pharm Sci
Affiliations
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Recent Articles
11.
Antiepileptic drugs reduce the efficacy of methotrexate chemotherapy through accelerated degradation of the reduced folate carrier by the ubiquitin-proteasome pathway
Halwachs S, Schaefer I, Seibel P, Honscha W
Chemotherapy . 2011 Sep; 57(4):345-56. PMID: 21912117
Background/aims: Concurrent treatment with methotrexate (MTX) and enzyme-inducing antiepileptic drugs including phenobarbital (PB) reduces the efficacy of MTX chemotherapy in cancer patients. We have shown that Reduced folate carrier (Rfc1)-mediated...
12.
The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier
Halwachs S, Lakoma C, Schafer I, Seibel P, Honscha W
Mol Pharmacol . 2011 Jul; 80(4):621-9. PMID: 21737571
Intrathecal methotrexate (MTX) has been associated with severe neurotoxicity. Because carrier-associated removal of MTX from the cerebrospinal fluid (CSF) into blood remains undefined, we determined the expression and function of...
13.
Dioxin mediates downregulation of the reduced folate carrier transport activity via the arylhydrocarbon receptor signalling pathway
Halwachs S, Lakoma C, Gebhardt R, Schafer I, Seibel P, Honscha W
Toxicol Appl Pharmacol . 2010 May; 246(1-2):100-6. PMID: 20451541
Dioxins such as 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) are common environmental contaminants known to regulate several genes via activation of the transcription factor aryl hydrocarbon receptor (AhR) associated with the development of numerous...
14.
Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators
Halwachs S, Kneuer C, Honscha W
Biochim Biophys Acta . 2007 May; 1768(6):1671-9. PMID: 17482559
The sodium dependent reduced folate carrier (Rfc1; Slc19a1) provides the major route for cellular uptake of reduced folates and antifolate drugs such as methotrexate (MTX) into various tissues. Despite its...
15.
Endogenous expression of liver-specific drug transporters for organic anions in the rat hepatocytoma fusion cell line HPCT-1E3
Halwachs S, Kneuer C, Honscha W
Eur J Cell Biol . 2005 Aug; 84(7):677-86. PMID: 16106911
HPCT-1E3 cells, a fusion cell line between primary rat hepatocytes and Fao Reuber hepatoma cells H35, are immortalized hybrid cells with many phenotypic properties of liver parenchyma including phase I...