Sander R Piersma
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Explore the profile of Sander R Piersma including associated specialties, affiliations and a list of published articles.
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144
Citations
3456
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Recent Articles
21.
Valles-Marti A, Mantini G, Manoukian P, Waasdorp C, Sarasqueta A, de Goeij-de Haas R, et al.
Cell Rep
. 2023 Jun;
42(6):112581.
PMID: 37269289
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a limited set of known driver mutations but considerable cancer cell heterogeneity. Phosphoproteomics provides a readout of aberrant signaling and has...
22.
Bhin J, Paes Dias M, Gogola E, Rolfs F, Piersma S, de Bruijn R, et al.
Cell Rep
. 2023 May;
42(5):112538.
PMID: 37209095
BRCA1 and BRCA2 both function in DNA double-strand break repair by homologous recombination (HR). Due to their HR defect, BRCA1/2-deficient cancers are sensitive to poly(ADP-ribose) polymerase inhibitors (PARPis), but they...
23.
Chatterjee M, Ozdemir S, Kunadt M, Koel-Simmelink M, Boiten W, Piepkorn L, et al.
Alzheimers Dement
. 2023 Apr;
19(11):4828-4840.
PMID: 37023079
Introduction: Extracellular vesicles (EVs) may propagate and modulate Alzheimer's disease (AD) pathology. We aimed to comprehensively characterize the proteome of cerebrospinal fluid (CSF) EVs to identify proteins and pathways altered...
24.
van der Wijngaart H, Jagga S, Dekker H, de Goeij R, Piersma S, Pham T, et al.
Cancer Med
. 2023 Mar;
12(9):10979-10989.
PMID: 36916528
Purpose: In precision oncology, tumor molecular profiles guide selection of therapy. Standardized snap freezing of tissue biospecimens is necessary to ensure reproducible, high-quality samples that preserve tumor biology for adequate...
25.
Pham T, Nguyen V, Vu D, Henneman A, Richardson R, Piersma S, et al.
Proteomics
. 2023 Mar;
23(7-8):e2200041.
PMID: 36906835
Accurate retention time (RT) prediction is important for spectral library-based analysis in data-independent acquisition mass spectrometry-based proteomics. The deep learning approach has demonstrated superior performance over traditional machine learning methods...
26.
Ho V, Rong M, Habjan E, Bommer S, Pham T, Piersma S, et al.
Biomolecules
. 2023 Feb;
13(2).
PMID: 36830581
The ESX-5 secretion system is essential for the viability and virulence of slow-growing pathogenic mycobacterial species. In this study, we identified a 1,2,4-oxadiazole derivative as a putative effector of the...
27.
Damen M, Meijers A, Keizer E, Piersma S, Jimenez C, Kuijl C, et al.
mBio
. 2022 Nov;
13(6):e0281922.
PMID: 36409073
Mycobacteria use specialized type VII secretion systems (T7SSs) to secrete proteins across their diderm cell envelope. One of the T7SS subtypes, named ESX-1, is a major virulence determinant in pathogenic...
28.
van Spanning R, Guan Q, Melkonian C, Gallant J, Polerecky L, Flot J, et al.
Nat Microbiol
. 2022 Nov;
7(12):2089-2100.
PMID: 36329197
So far, only members of the bacterial phyla Proteobacteria and Verrucomicrobia are known to grow methanotrophically under aerobic conditions. Here we report that this metabolic trait is also observed within...
29.
Brink H, van Senten J, De Vries-van Leeuwen I, da Costa Pereira D, Piersma S, Jimenez C, et al.
ACS Chem Biol
. 2022 Oct;
17(11):2972-2978.
PMID: 36255265
The cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein found overexpressed in many types of cancer. CIP2A has been shown to stabilize oncoproteins such as cMYC by shielding...
30.
Piersma S, Valles-Marti A, Rolfs F, Pham T, Henneman A, Jimenez C
Mass Spectrom Rev
. 2022 Sep;
43(4):725-751.
PMID: 36156810
Aberrant cellular signaling pathways are a hallmark of cancer and other diseases. One of the most important signaling mechanisms involves protein phosphorylation/dephosphorylation. Protein phosphorylation is catalyzed by protein kinases, and...