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Sanan Venkatesh

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Articles 22
Citations 182
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Recent Articles
1.
Burstein D, Tomasi S, Venkatesh S, Rizk M, Roussos P, Voloudakis G
medRxiv . 2025 Feb; PMID: 39974071
Importance: Researchers commonly use counts of diagnostic codes from EHR-linked biobanks to infer phenotypic status. However, these approaches overlook temporal changes in EHR data, such as the discontinuation or "dropout"...
2.
Voloudakis G, Lee K, Vicari J, Zhang W, Hoagland D, Venkatesh S, et al.
medRxiv . 2025 Jan; PMID: 39867394
Background: The development and approval of novel drugs are typically time-intensive and expensive. Leveraging a computational drug repurposing framework that integrates disease-relevant genetically regulated gene expression (GReX) and large longitudinal...
3.
Zeng B, Yang H, N M P, Venkatesh S, Mathur D, Auluck P, et al.
Res Sq . 2024 Dec; PMID: 39711543
Genetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression. Although bulk tissue studies have elucidated shared mechanisms of regulatory and disease-associated genetics,...
4.
Gorman B, Voloudakis G, Igo Jr R, Kinzy T, Halladay C, Bigdeli T, et al.
Nat Genet . 2024 Dec; 56(12):2659-2671. PMID: 39623103
To effectively reduce vision loss due to age-related macular generation (AMD) on a global scale, knowledge of its genetic architecture in diverse populations is necessary. A critical element, AMD risk...
5.
Maury E, Jones A, Seplyarskiy V, Nguyen T, Rosenbluh C, Bae T, et al.
Science . 2024 Oct; 386(6718):217-224. PMID: 39388546
Germline mutations modulate the risk of developing schizophrenia (SCZ). Much less is known about the role of mosaic somatic mutations in the context of SCZ. Deep (239×) whole-genome sequencing (WGS)...
6.
Bigdeli T, Chatzinakos C, Bendl J, Barr P, Venkatesh S, Gorman B, et al.
medRxiv . 2024 Sep; PMID: 39252912
Large-scale genome-wide association studies of schizophrenia have uncovered hundreds of associated loci but with extremely limited representation of African diaspora populations. We surveyed electronic health records of 200,000 individuals of...
7.
Verma A, Huffman J, Rodriguez A, Conery M, Liu M, Ho Y, et al.
Science . 2024 Jul; 385(6706):eadj1182. PMID: 39024449
One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and...
8.
Kang J, Castro V, Ripperger M, Venkatesh S, Burstein D, Linner R, et al.
Am J Psychiatry . 2024 May; 181(7):608-619. PMID: 38745458
Objective: Treatment-resistant depression (TRD) occurs in roughly one-third of all individuals with major depressive disorder (MDD). Although research has suggested a significant common variant genetic component of liability to TRD,...
9.
Girdhar K, Bendl J, Baumgartner A, Therrien K, Venkatesh S, Mathur D, et al.
Res Sq . 2023 Oct; PMID: 37886514
Non-coding variants increase risk of neuropsychiatric disease. However, our understanding of the cell-type specific role of the non-coding genome in disease is incomplete. We performed population scale (N=1,393) chromatin accessibility...
10.
Girdhar K, Bendl J, Baumgartner A, Therrien K, Venkatesh S, Mathur D, et al.
medRxiv . 2023 Oct; PMID: 37873320
Non-coding variants increase risk of neuropsychiatric disease. However, our understanding of the cell-type specific role of the non-coding genome in disease is incomplete. We performed population scale (N=1,393) chromatin accessibility...