Samuel Pattillo Smith
Overview
Explore the profile of Samuel Pattillo Smith including associated specialties, affiliations and a list of published articles.
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7
Citations
90
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0
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Recent Articles
1.
Smith S, Smith O, Mostafavi H, Peng D, Berg J, Edge M, et al.
bioRxiv
. 2025 Feb;
PMID: 39975133
Polygenic scores (PGSs) are being rapidly adopted for trait prediction in the clinic and beyond. PGSs are often thought of as capturing the direct genetic effect of one's genotype on...
2.
Smith S, Darnell G, Udwin D, Stamp J, Harpak A, Ramachandran S, et al.
Elife
. 2024 Jun;
13.
PMID: 38913556
LD score regression (LDSC) is a method to estimate narrow-sense heritability from genome-wide association study (GWAS) summary statistics alone, making it a fast and popular approach. In this work, we...
3.
Weine E, Smith S, Knowlton R, Harpak A
bioRxiv
. 2024 Feb;
PMID: 38370664
Genetic effects on complex traits may depend on context, such as age, sex, environmental exposures or social settings. However, it is often unclear if the extent of context dependency, or...
4.
Gopalan S, Smith S, Korunes K, Hamid I, Ramachandran S, Goldberg A
Philos Trans R Soc Lond B Biol Sci
. 2022 Apr;
377(1852):20200410.
PMID: 35430881
Over the past 50 years, geneticists have made great strides in understanding how our species' evolutionary history gave rise to current patterns of human genetic diversity classically summarized by Lewontin...
5.
Smith S, Shahamatdar S, Cheng W, Zhang S, Paik J, Graff M, et al.
Am J Hum Genet
. 2022 Mar;
109(5):871-884.
PMID: 35349783
Since 2005, genome-wide association (GWA) datasets have been largely biased toward sampling European ancestry individuals, and recent studies have shown that GWA results estimated from self-identified European individuals are not...
6.
Spierer A, Mossman J, Smith S, Crawford L, Ramachandran S, Rand D
PLoS Genet
. 2021 Mar;
17(3):e1008887.
PMID: 33735180
The winged insects of the order Diptera are colloquially named for their most recognizable phenotype: flight. These insects rely on flight for a number of important life history traits, such...
7.
McGuirl M, Smith S, Sandstede B, Ramachandran S
Genetics
. 2020 Apr;
215(2):511-529.
PMID: 32245788
Emerging large-scale biobanks pairing genotype data with phenotype data present new opportunities to prioritize shared genetic associations across multiple phenotypes for molecular validation. Past research, by our group and others,...
8.
Nakka P, Smith S, ODonnell-Luria A, McManus K, Mountain J, Ramachandran S, et al.
Am J Hum Genet
. 2019 Oct;
105(5):921-932.
PMID: 31607426
Meiotic nondisjunction and resulting aneuploidy can lead to severe health consequences in humans. Aneuploidy rescue can restore euploidy but may result in uniparental disomy (UPD), the inheritance of both homologs...