Samuel Kilcher
Overview
Explore the profile of Samuel Kilcher including associated specialties, affiliations and a list of published articles.
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27
Citations
1028
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Recent Articles
1.
Brown P, Kilcher S, Kim J, Loessner M, Kathariou S
Microbiol Resour Announc
. 2024 Jun;
13(7):e0035824.
PMID: 38916304
is notorious for persistence in food facilities. Phages can significantly impact the ecology of , but there is a dearth of genome sequence data for phages from food processing ecosystems....
2.
Fernbach J, Meile S, Kilcher S, Loessner M
Methods Mol Biol
. 2023 Dec;
2734:247-259.
PMID: 38066374
The rapid increase of circulating, antibiotic-resistant pathogens is a major ongoing global health crisis, and arguably, the end of the "golden age of antibiotics" is looming. This has led to...
3.
Meile S, Du J, Staubli S, Grossmann S, Koliwer-Brandl H, Piffaretti P, et al.
Nat Commun
. 2023 Jul;
14(1):4336.
PMID: 37474554
The rapid detection and species-level differentiation of bacterial pathogens facilitates antibiotic stewardship and improves disease management. Here, we develop a rapid bacteriophage-based diagnostic assay to detect the most prevalent pathogens...
4.
Du J, Meile S, Baggenstos J, Jaggi T, Piffaretti P, Hunold L, et al.
Nat Commun
. 2023 Jul;
14(1):4337.
PMID: 37474516
Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternative antimicrobials. However, phage-mediated killing is often limited by bacterial resistance development. Here,...
5.
Wohlfarth J, Feldmuller M, Schneller A, Kilcher S, Burkolter M, Meile S, et al.
Nat Microbiol
. 2023 Jan;
8(3):387-399.
PMID: 36717719
At the end of a lytic bacteriophage replication cycle in Gram-positive bacteria, peptidoglycan-degrading endolysins that cause explosive cell lysis of the host can also attack non-infected bystander cells. Here we...
6.
Meile S, Du J, Dunne M, Kilcher S, Loessner M
Curr Opin Virol
. 2021 Dec;
52:182-191.
PMID: 34952266
The alarming rise in antimicrobial resistance coupled with a lack of innovation in antibiotics has renewed interest in the development of alternative therapies to combat bacterial infections. Despite phage therapy...
7.
Lenneman B, Fernbach J, Loessner M, Lu T, Kilcher S
Curr Opin Biotechnol
. 2020 Dec;
68:151-159.
PMID: 33310655
The antimicrobial and therapeutic efficacy of bacteriophages is currently limited, mostly due to rapid emergence of phage-resistance and the inability of most phage isolates to bind and infect a broad...
8.
Meile S, Kilcher S, Loessner M, Dunne M
Viruses
. 2020 Aug;
12(9).
PMID: 32858938
Fast and reliable detection of bacterial pathogens in clinical samples, contaminated food products, and water supplies can drastically improve clinical outcomes and reduce the socio-economic impact of disease. As natural...
9.
Osuna B, Karambelkar S, Mahendra C, Sarbach A, Johnson M, Kilcher S, et al.
Cell Host Microbe
. 2020 Apr;
28(1):23-30.e5.
PMID: 32325051
Bacteriophages must rapidly deploy anti-CRISPR proteins (Acrs) to inactivate the RNA-guided nucleases that enforce CRISPR-Cas adaptive immunity in their bacterial hosts. Listeria monocytogenes temperate phages encode up to three anti-Cas9...
10.
Osuna B, Karambelkar S, Mahendra C, Christie K, Garcia B, Davidson A, et al.
Cell Host Microbe
. 2020 Apr;
28(1):31-40.e9.
PMID: 32325050
Bacterial CRISPR-Cas systems employ RNA-guided nucleases to destroy phage (viral) DNA. Phages, in turn, have evolved diverse "anti-CRISPR" proteins (Acrs) to counteract acquired immunity. In Listeria monocytogenes, prophages encode two...