Sampath K Loganathan
Overview
Explore the profile of Sampath K Loganathan including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
347
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0
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Recent Articles
1.
Dervovic D, Malik A, Chen E, Narimatsu M, Adler N, Afiuni-Zadeh S, et al.
Nat Commun
. 2023 Sep;
14(1):5404.
PMID: 37670013
No abstract available.
2.
Dervovic D, Malik A, Chen E, Narimatsu M, Adler N, Afiuni-Zadeh S, et al.
Nat Commun
. 2023 May;
14(1):3150.
PMID: 37258521
How the genetic landscape governs a tumor's response to immunotherapy remains poorly understood. To assess the immune-modulatory capabilities of 573 genes associated with altered cytotoxicity in human cancers, here we...
3.
Vujovic A, de Rooij L, Keyvani Chahi A, Chen H, Yee B, Loganathan S, et al.
Blood Cancer Discov
. 2023 Feb;
4(3):180-207.
PMID: 36763002
Significance: LSC-targeted therapies remain a significant unmet need in AML. We developed a stem-cell-adapted in vivo CRISPR screen to identify key LSC drivers. We uncover widespread RNA-binding protein dependencies in...
4.
Langille E, Al-Zahrani K, Ma Z, Liang M, Uuskula-Reimand L, Espin R, et al.
Cancer Discov
. 2022 Sep;
12(12):2930-2953.
PMID: 36108220
Significance: Infrequently mutated genes comprise most of the mutational burden in breast tumors but are poorly understood. In vivo CRISPR screening identified functional tumor suppressors that converged on epigenetic regulation....
5.
Michmerhuizen N, Heenan C, Wang J, Leonard E, Bellile E, Loganathan S, et al.
Oral Oncol
. 2022 Feb;
126:105770.
PMID: 35172244
No abstract available.
6.
Loganathan S, Schleicher K, Malik A, Quevedo R, Langille E, Teng K, et al.
Science
. 2020 Mar;
367(6483):1264-1269.
PMID: 32165588
In most human cancers, only a few genes are mutated at high frequencies; most are mutated at low frequencies. The functional consequences of these recurrent but infrequent "long tail" mutations...
7.
Malhotra D, Loganathan S, Chiu A, Lukowski C, Casey J
Sci Rep
. 2019 Jul;
9(1):9681.
PMID: 31273259
Two blinding corneal dystrophies, pediatric-onset congenital hereditary endothelial dystrophy (CHED) and some cases of late-onset Fuchs endothelial corneal dystrophy (FECD), are caused by SLC4A11 mutations. Three N-terminal SLC4A11 variants: v1,...
8.
Loganathan S, Schneider H, Morgan P, Deitmer J, Casey J
Am J Physiol Cell Physiol
. 2016 Aug;
311(5):C735-C748.
PMID: 27558157
SLC4A11, a member of the SLC4 family of bicarbonate transporters, is a widely expressed integral membrane protein, abundant in kidney and cornea. Mutations of SLC4A11 cause some cases of the...
9.
Chiu A, Mandziuk J, Loganathan S, Alka K, Casey J
Invest Ophthalmol Vis Sci
. 2015 Dec;
56(13):7739-53.
PMID: 26641551
Purpose: Protein misfolding, causing retention of nascent protein in the endoplasmic reticulum (ER), is the most common molecular phenotype for disease alleles of membrane proteins. Strategies are needed to identify...
10.
Loganathan S, Lukowski C, Casey J
Am J Physiol Cell Physiol
. 2015 Nov;
310(2):C161-74.
PMID: 26582474
Large cytoplasmic domains (CD) are a common feature among integral membrane proteins. In virtually all cases, these CD have a function (e.g., binding cytoskeleton or regulatory factors) separate from that...