In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 As a Therapeutic Target

Overview

Journal Blood Cancer Discov

Specialties Hematology
Oncology

Date 2023 Feb 10

PMID 36763002

Authors

Ana Vujovic

Laura de Rooij

Ava Keyvani Chahi

He Tian Chen

Brian A Yee

Sampath K Loganathan

Lina Liu

Derek C H Chan

Amanda Tajik

Emily Tsao

Steven Moreira

Pratik Joshi

Joshua Xu

Nicholas Wong

Zaldy Balde

Soheil Jahangiri

Sasan Zandi

Stefan Aigner

John E Dick

Mark D Minden

Daniel Schramek

Gene W Yeo

Kristin J Hope

Affiliations

Soon will be listed here.

Abstract

Significance: LSC-targeted therapies remain a significant unmet need in AML. We developed a stem-cell-adapted in vivo CRISPR screen to identify key LSC drivers. We uncover widespread RNA-binding protein dependencies in LSCs, including ELAVL1, which we identify as a novel therapeutic vulnerability through its regulation of mitochondrial metabolism. This article is highlighted in the In This Issue feature, p. 171.

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