Samantha M Carlisle
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Explore the profile of Samantha M Carlisle including associated specialties, affiliations and a list of published articles.
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12
Citations
156
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Recent Articles
1.
Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA)
Trainor P, Brambatti M, Carlisle S, Mullick A, Shah S, Kahlon T, et al.
J Am Coll Cardiol
. 2023 Mar;
81(13):1248-1259.
PMID: 36990544
Background: Angiotensinogen is the proximal precursor of the angiotensin peptide hormones of the renin-angiotensin-aldosterone system (RAAS). Clinical trials are ongoing targeting angiotensinogen for the treatment of hypertension and heart failure....
2.
Hart M, Quon E, Vigil A, Engstrom I, Newsom O, Davidsen K, et al.
Elife
. 2023 Mar;
12.
PMID: 36883551
The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating catabolic conversions of NAD +to NADH and anabolic production of aspartate, a key amino acid for cell proliferation....
3.
Carlisle S, Trainor P, Doll M, Hein D
Front Pharmacol
. 2022 Jan;
12:803254.
PMID: 35046826
Many cancers, including breast cancer, have shown differential expression of human arylamine -acetyltransferase 1 (NAT1). The exact effect this differential expression has on disease risk and progression remains unclear. While...
4.
Xu E, Boddu R, Abdelmotilib H, Sokratian A, Kelly K, Liu Z, et al.
Mol Neurodegener
. 2022 Jan;
17(1):7.
PMID: 35012605
Background: Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson's disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression in pro-inflammatory...
5.
Carlisle S, Qin H, Hendrickson R, Muwanguzi J, Lefkowitz E, Kennedy R, et al.
NPJ Parkinsons Dis
. 2021 Apr;
7(1):36.
PMID: 33850148
Increasing evidence supports the role of brain and systemic inflammation in the etiology of Parkinson disease (PD). We used gene expression profiling to examine the activation state of peripheral blood...
6.
Carlisle S, Trainor P, Hong K, Doll M, Hein D
Sci Rep
. 2020 Jun;
10(1):9804.
PMID: 32555504
Human arylamine N-acetyltransferase 1 (NAT1), present in all tissues, is classically described as a phase-II xenobiotic metabolizing enzyme but can also catalyze the hydrolysis of acetyl-Coenzyme A (acetyl-CoA) in the...
7.
Carlisle S, Trainor P, Doll M, Stepp M, Klinge C, Hein D
Mol Carcinog
. 2018 Jul;
57(11):1458-1466.
PMID: 29964355
Human arylamine N-acetyltransferase 1 (NAT1) is a phase II xenobiotic metabolizing enzyme found in almost all tissues. NAT1 can also hydrolyze acetyl-coenzyme A (acetyl-CoA) in the absence of an arylamine...
8.
Carlisle S, Hein D
Int J Oncol
. 2018 Jun;
53(2):694-702.
PMID: 29901116
The expression levels of estrogen receptor 1 (ESR1), arylamine N‑acetyltransferase 1 (NAT1), and arylamine N‑acetyltransferase 2 (NAT2) are implicated in breast cancer; however, their co-expression profiles in normal breast tissue,...
9.
Zhang X, Carlisle S, Doll M, Martin R, States J, Klinge C, et al.
J Pharmacol Exp Ther
. 2018 Jan;
365(1):84-93.
PMID: 29339455
N-acetyltransferase 1 (NAT1) is an enzyme that metabolizes carcinogens, which suggests a potential role in breast carcinogenesis. High expression in breast tumors is associated with estrogen receptor (ER+) and the...
10.
Stepp M, Doll M, Carlisle S, States J, Hein D
Mol Carcinog
. 2018 Jan;
57(4):549-558.
PMID: 29315819
Arylamine N-acetyltransferase 1 (NAT1) expression is reported to affect proliferation, invasiveness, and growth of cancer cells. MDA-MB-231 breast cancer cells were engineered such that NAT1 expression was elevated or suppressed,...