Marcus W Stepp
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Explore the profile of Marcus W Stepp including associated specialties, affiliations and a list of published articles.
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12
Citations
145
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Recent Articles
1.
Hong K, Gardner J, Doll M, Stepp M, Wilkey D, Benz F, et al.
Data Brief
. 2022 Nov;
45:108634.
PMID: 36426076
Arylamine -acetyltransferase 1 () is frequently upregulated in breast cancer. An unbiased analysis of proteomes of parental MDA-MB-231 breast cancer cells and two separate knockout (KO) cell lines were performed....
2.
Hong K, Gardner J, Doll M, Stepp M, Wilkey D, Benz F, et al.
Toxicol Rep
. 2022 Sep;
9:1566-1573.
PMID: 36158865
Previous studies have shown that inhibition or depletion of -acetyltransferase 1 (NAT1) in breast cancer cell lines leads to growth retardation both in vitro and in vivo, suggesting that NAT1...
3.
Stepp M, Salazar-Gonzalez R, Hong K, Doll M, Hein D
J Oncol
. 2019 Sep;
2019:3860426.
PMID: 31531019
Elevated expression of -acetyltransferase 1 (NAT1) is associated with invasive and lobular breast carcinomas as well as with bone metastasis following an epithelial-to-mesenchymal transition. We investigated the effect of NAT1...
4.
Carlisle S, Trainor P, Doll M, Stepp M, Klinge C, Hein D
Mol Carcinog
. 2018 Jul;
57(11):1458-1466.
PMID: 29964355
Human arylamine N-acetyltransferase 1 (NAT1) is a phase II xenobiotic metabolizing enzyme found in almost all tissues. NAT1 can also hydrolyze acetyl-coenzyme A (acetyl-CoA) in the absence of an arylamine...
5.
Stepp M, Doll M, Carlisle S, States J, Hein D
Mol Carcinog
. 2018 Jan;
57(4):549-558.
PMID: 29315819
Arylamine N-acetyltransferase 1 (NAT1) expression is reported to affect proliferation, invasiveness, and growth of cancer cells. MDA-MB-231 breast cancer cells were engineered such that NAT1 expression was elevated or suppressed,...
6.
Stepp M, Doll M, Samuelson D, Sanders M, States J, Hein D
BMC Cancer
. 2017 Apr;
17(1):233.
PMID: 28359264
Background: Recent investigations suggest role(s) of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer. Rat NAT2 is orthologous to human NAT1 and the gene products are functional homologs. We conducted...
7.
Carlisle S, Trainor P, Yin X, Doll M, Stepp M, States J, et al.
Metabolomics
. 2016 Nov;
12(7).
PMID: 27872580
Introduction: Human arylamine -acetyltransferase 1 (NAT1) is a phase II xenobiotic metabolizing enzyme found in almost all tissues. Expression of NAT1 is elevated in several cancers including breast cancer. However,...
8.
Stepp M, Mamaliga G, Doll M, States J, Hein D
Biochem Biophys Rep
. 2015 Aug;
3:45-50.
PMID: 26309907
Arylamine -acetyltransferases (NATs) are drug and xenobiotic metabolizing enzymes that catalyze the N-acetylation of arylamines and hydrazines and the O-acetylation of N-hydroxy-arylamines. Recently, studies report that human NAT1 and mouse...
9.
Stepp M, Folz R, Yu J, Zelko I
Biochim Biophys Acta
. 2014 Feb;
1843(6):1076-88.
PMID: 24530860
The human c10orf10 gene product, also known as decidual protein induced by progesterone (DEPP), is known to be differentially regulated in mouse tissues in response to hypoxia and oxidative stress,...
10.
Zelko I, Stepp M, Folz R
Gene
. 2013 Jul;
530(1):75-82.
PMID: 23886589
Extracellular superoxide dismutase (EC-SOD) is the main antioxidant enzyme in the extracellular matrix. We developed transgenic mice to analyze the EC-SOD promoter activity in vivo in real time and to...