Sam P Heywood
Overview
Explore the profile of Sam P Heywood including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
41
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0
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Recent Articles
1.
Dave E, Durrant O, Dhami N, Compson J, Broadbridge J, Archer S, et al.
MAbs
. 2023 Feb;
15(1):2160229.
PMID: 36788124
TrYbe® is an Fc-free therapeutic antibody format, capable of engaging up to three targets simultaneously, with long half-life conferred by albumin binding. This format is shown by small-angle X-ray scattering...
2.
Weatherill E, Cain K, Heywood S, Compson J, Heads J, Adams R, et al.
Protein Eng Des Sel
. 2012 May;
25(7):321-9.
PMID: 22586154
Engineered introduction of interface interchain disulphide bonds is perceived to be a simple method to increase the stability of single chain Fv (scFv). Six disulphide bond locations have been cited...
3.
Humphreys D, Heywood S, Henry A, Ait-Lhadj L, Antoniw P, Palframan R, et al.
Protein Eng Des Sel
. 2007 Apr;
20(5):227-34.
PMID: 17452434
Antigen-binding fragments (Fab') of antibodies can be site specifically PEGylated at thiols using cysteine reactive PEG-maleimide conjugates. For therapeutic Fab'-PEG, conjugation with 40 kDa of PEG at a single hinge...
4.
Humphreys D, Heywood S, King L, Bowering L, Turner J, Lane S
Protein Expr Purif
. 2004 Aug;
37(1):109-18.
PMID: 15294288
Escherichia coli is a widely used host for the heterologous expression of proteins of therapeutic and commercial interest. The scale and speed at which it can be cultured can result...