Sam Mesiano
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Explore the profile of Sam Mesiano including associated specialties, affiliations and a list of published articles.
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75
Citations
1868
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Recent Articles
11.
Severance A, Kinder J, Xin L, Burg A, Shao T, Pham G, et al.
iScience
. 2022 May;
25(6):104400.
PMID: 35637736
Pregnancy stimulates an intricately coordinated assortment of physiological changes to accommodate growth of the developing fetus, while simultaneously averting rejection of genetically foreign fetal cells and tissues. Despite increasing evidence...
12.
Libby V, Wilson R, Kresak A, Cameron C, Redline R, Mesiano S, et al.
F S Sci
. 2022 May;
2(2):198-206.
PMID: 35559753
Objective: To investigate the effect of superovulation with human chorionic gonadotropin (hCG) or gonadotropin-releasing hormone agonist (GnRHa) trigger on leukocyte density and expression of leukocyte-specific genes in the peri-implantation period...
13.
Lai P, Lei K, Zhan X, Sooranna G, Li J, Georgiou E, et al.
PLoS One
. 2021 Nov;
16(11):e0260119.
PMID: 34797869
High throughput sequencing has previously identified differentially expressed genes (DEGs) and enriched signalling networks in human myometrium for term (≥37 weeks) gestation labour, when defined as a singular state of...
14.
Shynlova O, Nadeem L, Dorogin A, Mesiano S, Lye S
Am J Obstet Gynecol
. 2021 Aug;
226(2):249.e1-249.e21.
PMID: 34418351
Background: Progesterone, acting via its nuclear receptors called progesterone receptors, promotes myometrial relaxation during pregnancy, and suspension of this activity triggers labor. We previously found that 20α-hydroxysteroid dehydrogenase causes a...
15.
Nadeem L, Balendran R, Dorogin A, Mesiano S, Shynlova O, Lye S
J Cell Mol Med
. 2021 Jun;
25(14):6773-6785.
PMID: 34114342
Metabolism of progesterone (P4) by the enzyme 20α hydroxysteroid dehydrogenase (20α-HSD) in myometrial cells is postulated to be a mechanism for P4 withdrawal, which occurs concomitant to uterine inflammation (physiologic...
16.
Zierden H, Ortiz J, DeLong K, Yu J, Li G, Dimitrion P, et al.
Sci Transl Med
. 2021 Jan;
13(576).
PMID: 33441428
Inflammation contributes to nearly 4 million global premature births annually. Here, we used a mouse model of intrauterine inflammation to test clinically used formulations, as well as engineered nanoformulations, for...
17.
Rokas A, Mesiano S, Tamam O, LaBella A, Zhang G, Muglia L
Elife
. 2020 Dec;
9.
PMID: 33380346
Eutherian mammals have characteristic lengths of gestation that are key for reproductive success, but relatively little is known about the processes that determine the timing of parturition, the process of...
18.
Sadovsky Y, Freathy R, Mahadevan-Jansen A, Mesiano S, Murray J, Muglia L
Am J Obstet Gynecol
. 2020 Aug;
223(6):951-952.
PMID: 32791123
No abstract available.
19.
Sadovsky Y, Mesiano S, Burton G, Lampl M, Murray J, Freathy R, et al.
Am J Obstet Gynecol
. 2020 Jun;
223(3):312-321.
PMID: 32565236
Recent revolutionary advances at the intersection of medicine, omics, data sciences, computing, epidemiology, and related technologies inspire us to ponder their impact on health. Their potential impact is particularly germane...
20.
Segal T, Amini P, Wang J, Peters G, Skomorovska-Prokvolit Y, Mainigi M, et al.
Biol Reprod
. 2020 Jan;
102(5):1122-1133.
PMID: 31995151
Gonadotropin-releasing hormone agonists (GnRHa) are used as an alternative to human chorionic gonadotropin (hCG) to trigger ovulation and decrease the risk of ovarian hyperstimulation syndrome. GnRHa is less potent at...