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Sam Lockhart

Explore the profile of Sam Lockhart including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 58
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Recent Articles
1.
Reed R, Zelek W, Morgan B, Whelehan G, Lockhart S, ORahilly S, et al.
Am J Physiol Endocrinol Metab . 2025 Mar; PMID: 40047170
Populations of Black African (BA) ancestry are disproportionately affected by cardiometabolic diseases, possibly due to dysregulation of the complement system. This study aimed to determine 1) relationships between fasting complement...
2.
Jia R, Lockhart S, Lam B, Zhao Y, Kentistou K, Gardner E, et al.
J Clin Endocrinol Metab . 2025 Mar; PMID: 40036808
Objectives: Clinical case-based studies have identified rare pathogenic variants in several genes as causes of severe early-onset obesity, but their penetrance and interaction with polygenic susceptibility in the general population...
3.
Griffiths H, Cardwell A, Richardson M, Barne M, Petrisor B, Usman A, et al.
Sci Rep . 2024 Nov; 14(1):27668. PMID: 39532941
Stress hyperglycaemia is common in critical illness. We have previously observed that increasing severity of respiratory failure in patients with severe COVID-19 is associated with increased insulin demand. Given previously...
4.
Gautheron J, Elsayed S, Pistorio V, Lockhart S, Zammouri J, Auclair M, et al.
Proc Natl Acad Sci U S A . 2024 Jun; 121(24):e2319301121. PMID: 38838011
Alcohol dehydrogenase 1B (ADH1B) is a primate-specific enzyme which, uniquely among the ADH class 1 family, is highly expressed both in adipose tissue and liver. Its expression in adipose tissue...
5.
Storas A, Andersen O, Lockhart S, Thielemann R, Gnesin F, Thambawita V, et al.
Diagnostics (Basel) . 2023 Jul; 13(14). PMID: 37510089
Deep neural networks are complex machine learning models that have shown promising results in analyzing high-dimensional data such as those collected from medical examinations. Such models have the potential to...
6.
Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison N, Wareham N, et al.
Nat Metab . 2023 Mar; 5(4):710. PMID: 36935425
No abstract available.
7.
Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison N, Wareham N, et al.
Nat Metab . 2023 Feb; 5(3):516-528. PMID: 36823471
Studying the plasma proteome as the intermediate layer between the genome and the phenome has the potential to identify new disease processes. Here, we conducted a cis-focused proteogenomic analysis of...
8.
Lockhart S, Wallace I, Nugent A, Black N, Quinn M, Johnston P
Ulster Med J . 2019 Oct; 88(3):157-161. PMID: 31619849
Introduction: Patient portals are online electronic medical record applications that allow patients greater control of their own health and encourage meaningful interaction with their healthcare providers. The uptake of this...
9.
Martinez K, Lockhart S, Davies M, Lindsay J, Dempster M
Psychol Health Med . 2017 Jun; 23(2):171-177. PMID: 28610449
The emotional distress associated with adjusting to and living with diabetes has been termed diabetes distress. Diabetes distress is associated with glycaemic control but interventions to reduce diabetes distress have...
10.
Berry E, Lockhart S, Davies M, Lindsay J, Dempster M
Postgrad Med J . 2015 Apr; 91(1075):278-83. PMID: 25827438
Diabetes distress is a rational emotional response to the threat of a life-changing illness. Distinct from depression, it is conceptually rooted in the demands of diabetes management and is a...