Sam H Au
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Explore the profile of Sam H Au including associated specialties, affiliations and a list of published articles.
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20
Citations
544
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Recent Articles
1.
Perea Paizal J, Au S, Bakal C
Sci Rep
. 2024 Jun;
14(1):14793.
PMID: 38926422
During metastatic dissemination, circulating tumour cells (CTCs) enter capillary beds, where they experience mechanical constriction forces. The transient and persistent effects of these forces on CTCs behaviour remain poorly understood....
2.
Vrynas A, Bazban-Shotorbani S, Arfan S, Satia K, Ashna M, Zhang A, et al.
bioRxiv
. 2024 Apr;
PMID: 38659882
Circulating tumor cells (CTCs) and their clusters are the drivers of metastasis, but we have an incomplete understanding of how they interact with capillary beds. Using microfluidic models mimicking human...
3.
Au S
Methods Mol Biol
. 2023 Jun;
2679:15-23.
PMID: 37300606
Circulating tumor cell (CTC) clusters are rare yet potent initiators of metastasis and may be useful as clinical biomarkers. Numerous techniques have been developed to isolate individual circulating tumor cells...
4.
Kawara S, Cunningham B, Bezer J, Kc N, Zhu J, Tang M, et al.
Small
. 2023 Jun;
19(42):e2301163.
PMID: 37267935
Microvascular networks are essential for the efficient transport of nutrients, waste products, and drugs throughout the body. Wire-templating is an accessible method for generating laboratory models of these blood vessel...
5.
Ashby J, Schmidt J, Kc N, Kurum A, Koch C, Harari A, et al.
Adv Healthc Mater
. 2022 Jun;
11(16):e2200169.
PMID: 35657072
No T cell receptor (TCR) T cell therapies have obtained clinical approval. The lack of strategies capable of selecting and recovering potent T cell candidates may be a contributor to...
6.
Varotsos Vrynas A, Perea Paizal J, Bakal C, Au S
Clin Exp Metastasis
. 2021 Jul;
38(4):337-342.
PMID: 34241735
The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary...
7.
Perea Paizal J, Au S, Bakal C
Br J Cancer
. 2020 Dec;
124(1):58-65.
PMID: 33257836
During metastasis, tumour cells navigating the vascular circulatory system-circulating tumour cells (CTCs)-encounter capillary beds, where they start the process of extravasation. Biomechanical constriction forces exerted by the microcirculation compromise the...
8.
Zargaryan A, Farhoudi N, Haworth G, Ashby J, Au S
Sci Rep
. 2020 Oct;
10(1):18379.
PMID: 33110199
3D printed and paper-based microfluidics are promising formats for applications that require portable miniaturized fluid handling such as point-of-care testing. These two formats deployed in isolation, however, have inherent limitations...
9.
Tessier S, Weng L, Moyo W, Au S, Wong K, Angpraseuth C, et al.
ACS Biomater Sci Eng
. 2019 Sep;
4(8):3006-3015.
PMID: 31544149
Cryopreservation is of significance in areas including tissue engineering, regenerative medicine, and organ transplantation. We investigated endothelial cell attachment and membrane integrity in a microvasculature model at high subzero temperatures...
10.
Au S, Edd J, Haber D, Maheswaran S, Stott S, Toner M
Curr Opin Biomed Eng
. 2017 Dec;
3:13-19.
PMID: 29226271
The vast majority of cancer associated deaths result from metastasis, yet the behaviors of its most potent cellular driver, circulating tumor cell clusters, are only beginning to be revealed. This...