Sam E Williams
Overview
Explore the profile of Sam E Williams including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
150
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Recent Articles
1.
Williams S, Faurdal D, Jorgensen T, Back C, Rooms L, Hayes M, et al.
Microbiol Resour Announc
. 2025 Jan;
14(2):e0115824.
PMID: 39812635
Here, we report the resequencing, assembly, and annotation of two actinomycete genomes containing abyssomicin gene clusters. DSM 45791 with a circular chromosome of 11,681,598 bp and 4 circular plasmids (14,175-207,548...
2.
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, et al.
Nucleic Acids Res
. 2024 Dec;
53(D1):D678-D690.
PMID: 39657789
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is...
3.
Williams S, Varliero G, Lurgi M, Stach J, Race P, Curnow P
Microbiology (Reading)
. 2024 Jul;
170(7).
PMID: 39073401
Sponges (phylum Porifera) harbour specific microbial communities that drive the ecology and evolution of the host. Understanding the structure and dynamics of these communities is emerging as a primary focus...
4.
Maleckis M, Wibowo M, Williams S, Gotfredsen C, Sigrist R, Souza L, et al.
ACS Chem Biol
. 2024 May;
19(6):1303-1310.
PMID: 38743035
Isoquinolinequinones represent an important family of natural alkaloids with profound biological activities. Heterologous expression of a rare bifunctional indole prenyltransferase/tryptophan indole-lyase enzyme from P8-A2 in J1074 led to the activation...
5.
Zorn K, Back C, Barringer R, Chadimova V, Manzo-Ruiz M, Mbatha S, et al.
Chembiochem
. 2023 Jun;
24(14):e202300382.
PMID: 37305956
Stereoselective carbon-carbon bond forming reactions are quintessential transformations in organic synthesis. One example is the Diels-Alder reaction, a [4+2] cycloaddition between a conjugated diene and a dienophile to form cyclohexenes....
6.
Williams S, Back C, Best E, Mantell J, Stach J, Williams T, et al.
Microb Genom
. 2023 May;
9(5).
PMID: 37166955
The deep sea is known to host novel bacteria with the potential to produce a diverse array of undiscovered natural products. Thus, understanding these bacteria is of broad interest in...
7.
Back C, Stennett H, Williams S, Wang L, Ojeda Gomez J, Abdulle O, et al.
Mar Drugs
. 2023 Apr;
21(4).
PMID: 37103398
After publication of this article [...].
8.
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters
Terlouw B, Blin K, Navarro-Munoz J, Avalon N, Chevrette M, Egbert S, et al.
Nucleic Acids Res
. 2022 Nov;
51(D1):D603-D610.
PMID: 36399496
With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs,...
9.
A New Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge
Back C, Stennett H, Williams S, Wang L, Ojeda Gomez J, Abdulle O, et al.
Mar Drugs
. 2021 Mar;
19(2).
PMID: 33670308
To tackle the growing problem of antibiotic resistance, it is essential to identify new bioactive compounds that are effective against resistant microbes and safe to use. Natural products and their...
10.
Williams S, Stennett H, Back C, Tiwari K, Ojeda Gomez J, Challand M, et al.
Antibiotics (Basel)
. 2020 Aug;
9(8).
PMID: 32823674
The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due to the significant logistical and operational...