Sally J Leevers
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Explore the profile of Sally J Leevers including associated specialties, affiliations and a list of published articles.
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23
Citations
1579
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Recent Articles
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Lin J, Mitchell N, Kalcina M, Tchoubrieva E, Stewart M, Marygold S, et al.
PLoS Genet
. 2011 Dec;
7(12):e1002408.
PMID: 22194697
The ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomal proteins (Rps) act as tumour suppressors in Drosophila and...
3.
Cheng L, Bailey A, Leevers S, Ragan T, Driscoll P, Gould A
Cell
. 2011 Aug;
146(3):435-47.
PMID: 21816278
Developing animals survive periods of starvation by protecting the growth of critical organs at the expense of other tissues. Here, we use Drosophila to explore the as yet unknown mechanisms...
4.
Cully M, Genevet A, Warne P, Treins C, Liu T, Bastien J, et al.
Mol Cell Biol
. 2009 Nov;
30(2):481-95.
PMID: 19917724
The target of rapamycin (TOR) complex 1 (TORC1) signaling pathway is a critical regulator of translation and cell growth. To identify novel components of this pathway, we performed a kinome-wide...
5.
Marygold S, Roote J, Reuter G, Lambertsson A, Ashburner M, Millburn G, et al.
Genome Biol
. 2007 Oct;
8(10):R216.
PMID: 17927810
Background: Mutations in genes encoding ribosomal proteins (RPs) have been shown to cause an array of cellular and developmental defects in a variety of organisms. In Drosophila melanogaster, disruption of...
6.
Giannakou M, Goss M, Jacobson J, Vinti G, Leevers S, Partridge L
Aging Cell
. 2007 May;
6(4):429-38.
PMID: 17465980
The insulin/insulin growth factor (IGF)-like signaling (IIS) pathway has a conserved role in regulating lifespan in Caenorhabditis elegans, Drosophila and mice. Extension of lifespan by reduced IIS has been shown...
7.
Andersen D, Leevers S
J Biol Chem
. 2007 Mar;
282(20):14752-60.
PMID: 17392269
The Drosophila gene, pixie, is an essential gene required for normal growth and translation. Pixie is the fly ortholog of human RLI, which was first identified as an RNase L...
8.
Wu M, Cully M, Andersen D, Leevers S
EMBO J
. 2006 Dec;
26(2):371-9.
PMID: 17183368
In Drosophila and mammals, insulin signalling can increase growth, progression through G1/S, cell size and tissue size. Here, we analyse the way insulin affects cell size and cell-cycle progression in...
9.
Williams K, Busto M, Suster M, So A, Ben-Shahar Y, Leevers S, et al.
Proc Natl Acad Sci U S A
. 2006 Oct;
103(43):15911-5.
PMID: 17043223
This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110...
10.
Orme M, Alrubaie S, Bradley G, Walker C, Leevers S
Nat Cell Biol
. 2006 Oct;
8(11):1298-302.
PMID: 17041587
Class I phosphoinositide 3-kinases (PI(3)Ks) are activated through associated adaptor molecules in response to G protein-coupled and tyrosine kinase receptor signalling. They contain Ras-binding domains (RBDs) and can also be...