Salil A Lachke
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Explore the profile of Salil A Lachke including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Rayee D, Hwang D, Chang W, Karp I, Zhao Y, Bowman T, et al.
bioRxiv
. 2025 Jan;
PMID: 39829794
RNA-binding proteins (RBPs) are critical regulators of mRNAs controlling all processes such as RNA transcription, transport, localization, translation, mRNA:ncRNA interactions, and decay. Cellular differentiation is driven by tissue-specific and/or tissue-preferred...
2.
Shrestha S, Lachke S
Methods Mol Biol
. 2024 Sep;
2848:37-58.
PMID: 39240515
Several protocols have been established for the generation of lens organoids from embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and other cells with regenerative potential in humans or...
3.
Upreti A, Padula S, Weaver J, Wagner B, Kneller A, Petulla A, et al.
Cells
. 2024 Jul;
13(14.
PMID: 39056803
Adding 50% vitreous humor to the media surrounding lens explants induces fiber cell differentiation and a significant immune/inflammatory response. While loss blocks differentiation in lens epithelial explants, this blockage is...
4.
Choquet H, Duot M, Herrera V, Shrestha S, Meyers T, Hoffmann T, et al.
Front Ophthalmol (Lausanne)
. 2024 Jul;
4:1362350.
PMID: 38984127
Introduction: Cataract is the leading cause of blindness among the elderly worldwide. Twin and family studies support an important role for genetic factors in cataract susceptibility with heritability estimates up...
5.
Alade A, Mossey P, Awotoye W, Busch T, Oladayo A, Aladenika E, et al.
Sci Rep
. 2024 Jun;
14(1):14279.
PMID: 38902479
Non-syndromic orofacial clefts (NSOFCs) are common birth defects with a complex etiology. While over 60 common risk loci have been identified, they explain only a small proportion of the heritability...
6.
Upreti A, Hoang T, Li M, Tangeman J, Dierker D, Wagner B, et al.
Invest Ophthalmol Vis Sci
. 2024 Apr;
65(4):42.
PMID: 38683565
Purpose: Despite strong evidence demonstrating that normal lens development requires regulation governed by microRNAs (miRNAs), the functional role of specific miRNAs in mammalian lens development remains largely unexplored. Methods: A...
7.
Alade A, Peter T, Busch T, Awotoye W, Anand D, Abimbola O, et al.
Genet Epidemiol
. 2024 Apr;
48(6):258-269.
PMID: 38634654
Nonsyndromic orofacial clefts (NSOFCs) represent a large proportion (70%-80%) of all OFCs. They can be broadly categorized into nonsyndromic cleft lip with or without cleft palate (NSCL/P) and nonsyndromic cleft...
8.
Alade A, Mossey P, Awotoye W, Busch T, Oladayo A, Aladenika E, et al.
Res Sq
. 2024 Mar;
PMID: 38464065
Non-syndromic orofacial clefts (NSOFCs) are common birth defects with a complex etiology. While over 60 common risk loci have been identified, they explain only a small proportion of the heritability...
9.
Upreti A, Hoang T, Li M, Tangeman J, Dierker D, Wagner B, et al.
bioRxiv
. 2024 Feb;
PMID: 38352453
Purpose: Despite strong evidence demonstrating that normal lens development requires regulation governed by miRNAs, the functional role of specific miRNAs in mammalian lens development remains largely unexplored. Methods: A comprehensive...
10.
Tangeman J, Rebull S, Grajales-Esquivel E, Weaver J, Bendezu-Sayas S, Robinson M, et al.
Development
. 2024 Jan;
151(1).
PMID: 38180241
Ocular lens development entails epithelial to fiber cell differentiation, defects in which cause congenital cataracts. We report the first single-cell multiomic atlas of lens development, leveraging snRNA-seq, snATAC-seq and CUT&RUN-seq...