Sailendra N Nichenametla
Overview
Explore the profile of Sailendra N Nichenametla including associated specialties, affiliations and a list of published articles.
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17
Citations
889
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Recent Articles
1.
Mattocks D, Ommi N, Malloy V, Nichenametla S
Geroscience
. 2024 Sep;
PMID: 39294474
Protein folding in the endoplasmic reticulum (ER) requires a high ratio of oxidized to reduced glutathione (GSSG/rGSH). Since the GSSG/rGSH depends on total glutathione (tGSH = GSSG + rGSH) levels,...
2.
Dong Z, Richie Jr J, Gao X, Al-Shaar L, Nichenametla S, Shen B, et al.
J Nutr
. 2023 Feb;
152(11):2419-2428.
PMID: 36774108
Background: Cross-sectional studies have suggested that consumption of sulfur amino acids (SAAs), including methionine and cysteine, is associated with a higher risk of type 2 diabetes (T2D) in humans and...
3.
Nichenametla S, Mattocks D, Cooke D, Midya V, Malloy V, Mansilla W, et al.
Aging Cell
. 2022 Nov;
21(12):e13739.
PMID: 36403077
Decreasing the dietary intake of methionine exerts robust anti-adiposity effects in rodents but modest effects in humans. Since cysteine can be synthesized from methionine, animal diets are formulated by decreasing...
4.
Nichenametla S, Mattocks D, Midya V, Shneyder J
J Gerontol A Biol Sci Med Sci
. 2020 Oct;
76(11):1922-1929.
PMID: 33106871
Diet can affect health and longevity by altering the gut microbiome profile. Sulfur amino acid restriction (SAAR), like caloric restriction, extends lifespan. But, its effect on the gut microbiome profile...
5.
Nichenametla S, Mattocks D, Malloy V
Aging Cell
. 2020 Jun;
19(7):e13177.
PMID: 32573078
Trade-offs in life-history traits are clinically and mechanistically important. Sulfur amino acid restriction (SAAR) extends lifespan. But whether this benefit comes at the cost of other traits including stress resistance...
6.
Cooke D, Mattocks D, Nichenametla S, Anunciado-Koza R, Koza R, Ables G
Obesity (Silver Spring)
. 2020 Apr;
28(6):1075-1085.
PMID: 32348021
Objective: Identifying novel approaches to combat obesity is important to improve health span. It was hypothesized that methionine restriction (MR) will induce weight loss in obese mice by reducing adipose...
7.
Gao X, Sanderson S, Dai Z, Reid M, Cooper D, Lu M, et al.
Nature
. 2019 Aug;
572(7769):397-401.
PMID: 31367041
Nutrition exerts considerable effects on health, and dietary interventions are commonly used to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic component, the principles that define whether...
8.
Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width
Dai Z, Mentch S, Gao X, Nichenametla S, Locasale J
Nat Commun
. 2018 May;
9(1):1955.
PMID: 29769529
Nutrition and metabolism are known to influence chromatin biology and epigenetics through post-translational modifications, yet how this interaction influences genomic architecture and connects to gene expression is unknown. Here we...
9.
Nichenametla S, Mattocks D, Malloy V, Pinto J
Ann N Y Acad Sci
. 2018 Jan;
1418(1):80-94.
PMID: 29377163
The mechanisms underlying life span extension by sulfur amino acid restriction (SAAR) are unclear. Cysteine and methionine are essential for the biosynthesis of proteins and glutathione (GSH), a major redox...
10.
Mattocks D, Mentch S, Shneyder J, Ables G, Sun D, Richie Jr J, et al.
Exp Gerontol
. 2016 Dec;
88:1-8.
PMID: 27940170
Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1...