Sagar Sengupta
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Explore the profile of Sagar Sengupta including associated specialties, affiliations and a list of published articles.
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Articles
51
Citations
1399
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Recent Articles
1.
Agrawal R, Sengupta S
EMBO J
. 2025 Mar;
PMID: 40038454
The DREAM repressor complex regulates genes involved in the cell cycle and DNA repair, vital for maintaining genome stability. Although it mediates p53-driven repression through the canonical p53-p21-Rb axis, the...
2.
Agrawal R, Agarwal H, Mukherjee C, Chakraborty B, Sharma V, Tripathi V, et al.
Nucleic Acids Res
. 2025 Feb;
53(4).
PMID: 39997217
Upon exposure to ionizing irradiation, the MRE11-RAD50-NBS1 complex potentiates the recruitment of ATM (ataxia-telangiectasia mutated) kinase to the double-strand breaks. We show that the lack of BLM causes a decrease...
3.
Kumari N, Kaur E, Raghavan S, Sengupta S
Curr Opin Pharmacol
. 2024 Dec;
80:102496.
PMID: 39724838
DNA damage signaling is a highly coordinated cellular process which is required for the removal of DNA lesions. Amongst the different types of DNA damage, double-strand breaks (DSBs) are the...
4.
Yadav P, Rana K, Nardini V, Khan A, Pani T, Kar A, et al.
J Control Release
. 2024 Mar;
368:548-565.
PMID: 38462044
Cancer treatment is challenged due to immunosuppressive inflammatory tumour microenvironment (TME) caused by infiltration of tumour-promoting and inhibition of tumour-inhibiting immune cells. Here, we report the engineering of chimeric nanomicelles...
5.
Kaur E, Agrawal R, Arun R, Madhavan V, Srivastava V, Kumar D, et al.
J Clin Invest
. 2024 Feb;
134(8).
PMID: 38421735
RAD54 and BLM helicase play pivotal roles during homologous recombination repair (HRR) to ensure genome maintenance. BLM amino acids (aa 181-212) interact with RAD54 and enhance its chromatin remodeling activity....
6.
Hussain M, Mohammed A, Saifi S, Priya S, Sengupta S
J Biol Chem
. 2023 Jul;
299(9):105087.
PMID: 37495109
Mutations in the DNA helicase RECQL4 lead to Rothmund-Thomson syndrome (RTS), a disorder characterized by mitochondrial dysfunctions, premature aging, and genomic instability. However, the mechanisms by which these mutations lead...
7.
Kar A, Jain D, Kumar S, Rajput K, Pal S, Rana K, et al.
Sci Adv
. 2023 Jun;
9(26):eadf2746.
PMID: 37390205
Treatment of triple-negative breast cancer (TNBC) is challenging because of its "COLD" tumor immunosuppressive microenvironment (TIME). Here, we present a hydrogel-mediated localized delivery of a combination of docetaxel (DTX) and...
8.
Mondal I, Fatima S, Priya S, Sengupta S, Khare S, Kulshreshtha R
ACS Biomater Sci Eng
. 2023 Apr;
9(5):2558-2571.
PMID: 37067339
Glioblastoma (GBM) is a deadly tumor of the central nervous system (CNS) having a dismal prognosis. miRNA-based therapeutics hold immense potential for GBM therapy; however, its delivery remains a daunting...
9.
Hussain M, Saifi S, Mohammed A, Sengupta S
STAR Protoc
. 2022 Sep;
3(4):101710.
PMID: 36136752
Mitochondrial polymerase gamma (PolγA) is the only replicative polymerase in mitochondria. To determine PolγA ubiquitylation in cells, Flag-PolγA and MITOL are overexpressed, and subsequently the immunoprecipitated Flag-PolγA is checked for...
10.
Rajanala K, Sarkar A, Jhingan G, Priyadarshini R, Jalan M, Sengupta S, et al.
J Cell Sci
. 2022 Mar;
135(6).
PMID: 35344051
No abstract available.