Safia Zedek
Overview
Explore the profile of Safia Zedek including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
27
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0
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Recent Articles
1.
Dominguez-Molina L, Kurata T, Cepauskas A, Echemendia-Blanco D, Zedek S, Talavera-Perez A, et al.
Nat Chem Biol
. 2024 Jun;
21(2):182-192.
PMID: 38834893
Toxic small alarmone synthetase (toxSAS) enzymes constitute a family of bacterial effectors present in toxin-antitoxin and secretion systems. toxSASs act through either translation inhibition mediated by pyrophosphorylation of transfer RNA...
2.
Cayron J, Oms T, Schlechtweg T, Zedek S, Van Melderen L
Sci Adv
. 2024 Mar;
10(13):eadk1577.
PMID: 38536908
Bactericidal antibiotics can cause metabolic perturbations that contribute to antibiotic-induced lethality. The molecular mechanism underlying these downstream effects remains unknown. Here, we show that ofloxacin, a fluoroquinolone that poisons DNA...
3.
Rousseau C, Fraikin N, Zedek S, Van Melderen L
Antimicrob Agents Chemother
. 2023 Oct;
67(10):e0032923.
PMID: 37787525
Bacterial persistence to antibiotics defines the ability of small sub-populations of sensitive cells within an isogenic population to survive high doses of bactericidal antibiotics. Here, we investigated the importance of...
4.
Ainelo A, Caballero-Montes J, Bulvas O, Ernits K, Coppieters t Wallant K, Takada H, et al.
Sci Adv
. 2023 Jan;
9(3):eade4077.
PMID: 36652515
Rel stringent factors are bifunctional ribosome-associated enzymes that catalyze both synthesis and hydrolysis of the alarmones (p)ppGpp. Besides the allosteric control by starved ribosomes and (p)ppGpp, Rel is regulated by...
5.
Tamman H, Ernits K, Roghanian M, Ainelo A, Julius C, Perrier A, et al.
Nat Chem Biol
. 2022 Dec;
19(3):334-345.
PMID: 36470996
Stringent factors orchestrate bacterial cell reprogramming through increasing the level of the alarmones (p)ppGpp. In Beta- and Gammaproteobacteria, SpoT hydrolyzes (p)ppGpp to counteract the synthetase activity of RelA. However, structural...
6.
Jurenas D, Fraikin N, Goormaghtigh F, De Bruyn P, Vandervelde A, Zedek S, et al.
mBio
. 2021 Nov;
12(6):e0294721.
PMID: 34844426
Type II toxin-antitoxin (TA) systems are classically composed of two genes that encode a toxic protein and a cognate antitoxin protein. Both genes are organized in an operon whose expression...