Sadhana Samant
Overview
Explore the profile of Sadhana Samant including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
1374
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0
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Recent Articles
1.
Pillai V, Samant S, Hund S, Gupta M, Gupta M
Aging (Albany NY)
. 2021 May;
13(9):12334-12358.
PMID: 33934090
Sirtuins have been shown to regulate the aging process. We have previously demonstrated that Sirt6 blocks the pressure overload-induced cardiac hypertrophy in mice. Here, we show that Sirt6 can also...
2.
Kanwal A, Pillai V, Samant S, Gupta M, Gupta M
FASEB J
. 2019 Jul;
33(10):10872-10888.
PMID: 31318577
Sirtuins (Sirts) are implicated in regulating a myriad of biologic functions ranging from cell growth and metabolism to longevity. Here, we show that nuclear Sirt, Sirt6, and mitochondrial Sirt, Sirt3,...
3.
Pillai V, Kanwal A, Fang Y, Sharp W, Samant S, Arbiser J, et al.
Oncotarget
. 2017 Apr;
8(21):34082-34098.
PMID: 28423723
Doxorubicin is the chemotherapeutic drug of choice for a wide variety of cancers, and cardiotoxicity is one of the major side effects of doxorubicin treatment. One of the main cellular...
4.
Bindu S, Pillai V, Kanwal A, Samant S, Mutlu G, Verdin E, et al.
Am J Physiol Lung Cell Mol Physiol
. 2016 Nov;
312(1):L68-L78.
PMID: 27815257
Myofibroblast differentiation is a key process in the pathogenesis of fibrotic diseases. Transforming growth factor-β (TGF-β) is a powerful inducer of myofibroblast differentiation and is implicated in pathogenesis of tissue...
5.
Pillai V, Bindu S, Sharp W, Fang Y, Kim G, Gupta M, et al.
Am J Physiol Heart Circ Physiol
. 2016 Feb;
310(8):H962-72.
PMID: 26873966
Doxorubicin (Doxo) is a chemotherapeutic drug widely used to treat variety of cancers. One of the most serious side effects of Doxo is its dose-dependent and delayed toxicity to the...
6.
Sundaresan N, Bindu S, Pillai V, Samant S, Pan Y, Huang J, et al.
Mol Cell Biol
. 2015 Dec;
36(5):678-92.
PMID: 26667039
Tissue fibrosis is a major cause of organ dysfunction during chronic diseases and aging. A critical step in this process is transforming growth factor β1 (TGF-β1)-mediated transformation of fibroblasts into...
7.
Pillai V, Samant S, Sundaresan N, Raghuraman H, Kim G, Bonner M, et al.
Nat Commun
. 2015 Apr;
6:6656.
PMID: 25871545
Honokiol (HKL) is a natural biphenolic compound derived from the bark of magnolia trees with anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective properties. Here we show that HKL blocks agonist-induced and pressure...
8.
Pillai V, Sundaresan N, Kim G, Samant S, Moreno-Vinasco L, Garcia J, et al.
Am J Physiol Heart Circ Physiol
. 2012 Dec;
304(3):H415-26.
PMID: 23203961
Nicotinamide phosphoribosyltransferase (Nampt) is an important coenzyme involved in cellular redox reactions. Inside the cell, Nampt (iNampt) functions as a rate-limiting enzyme in the NAD salvage pathway, and outside the...
9.
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
Sundaresan N, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, et al.
Nat Med
. 2012 Oct;
18(11):1643-50.
PMID: 23086477
Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the development of various diseases, including heart failure. However, the molecular mechanisms that regulate activation of this signaling pathway...
10.
Sundaresan N, Pillai V, Wolfgeher D, Samant S, Vasudevan P, Parekh V, et al.
Sci Signal
. 2011 Jul;
4(182):ra46.
PMID: 21775285
Signaling through the kinase Akt regulates many biological functions. Akt is activated during growth factor stimulation through a process that requires binding of Akt to phosphatidylinositol 3,4,5-trisphosphate (PIP(3)), which promotes...