Sachel Mok
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Explore the profile of Sachel Mok including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Okombo J, Mok S, Qahash T, Yeo T, Bath J, Orchard L, et al.
PLoS Pathog
. 2022 Oct;
18(10):e1010926.
PMID: 36306287
The emergence of Plasmodium falciparum parasite resistance to dihydroartemisinin + piperaquine (PPQ) in Southeast Asia threatens plans to increase the global use of this first-line antimalarial combination. High-level PPQ resistance...
12.
Wicht K, Small-Saunders J, Hagenah L, Mok S, Fidock D
J Infect Dis
. 2022 Sep;
226(11):2021-2029.
PMID: 36082431
Background: Additional therapeutic strategies could benefit efforts to reverse the recent increase in malaria cases in sub-Saharan Africa, which mostly affects young children. A primary candidate is dihydroartemisinin + piperaquine...
13.
Barber B, Fernandez M, Patel H, Barcelo C, Woolley S, Patel H, et al.
Lancet Infect Dis
. 2022 Mar;
22(6):879-890.
PMID: 35247321
Background: New antimalarials with novel mechanisms of action are needed to combat the emergence of drug resistance. Triaminopyrimidines comprise a novel antimalarial class identified in a high-throughput screen against asexual...
14.
Kanai M, Yeo T, Asua V, Rosenthal P, Fidock D, Mok S
Antimicrob Agents Chemother
. 2021 Oct;
66(1):e0116321.
PMID: 34694871
Research efforts to combat antimalarial drug resistance rely on quick, robust, and sensitive methods to genetically characterize Plasmodium falciparum parasites. We developed a single-nucleotide polymorphism (SNP)-based genotyping method that can...
15.
Murithi J, Pascal C, Bath J, Boulenc X, Gnadig N, Pasaje C, et al.
Sci Transl Med
. 2021 Jul;
13(603).
PMID: 34290058
The emergence and spread of resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of...
16.
Stokes B, Dhingra S, Rubiano K, Mok S, Straimer J, Gnadig N, et al.
Elife
. 2021 Jul;
10.
PMID: 34279219
The emergence of mutant K13-mediated artemisinin (ART) resistance in malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, propeller genotyping confirms the emergence of the R561H...
17.
Murithi J, Deni I, Pasaje C, Okombo J, Bridgford J, Gnadig N, et al.
Cell Chem Biol
. 2021 Jul;
29(5):824-839.e6.
PMID: 34233174
Widespread Plasmodium falciparum resistance to first-line antimalarials underscores the vital need to develop compounds with novel modes of action and identify new druggable targets. Here, we profile five compounds that...
18.
Okaniwa M, Shibata A, Ochida A, Akao Y, White K, Shackleford D, et al.
ACS Infect Dis
. 2021 Apr;
7(6):1680-1689.
PMID: 33929818
Prolyl-tRNA synthetase (PRS) is a clinically validated antimalarial target. Screening of a set of PRS ATP-site binders, initially designed for human indications, led to identification of 1-(pyridin-4-yl)pyrrolidin-2-one derivatives representing a...
19.
Palmer M, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, et al.
J Med Chem
. 2021 Apr;
64(9):6085-6136.
PMID: 33876936
Dihydroorotate dehydrogenase (DHODH) has been clinically validated as a target for the development of new antimalarials. Experience with clinical candidate triazolopyrimidine DSM265 () suggested that DHODH inhibitors have great potential...
20.
3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum
Knaab T, Held J, Burckhardt B, Rubiano K, Okombo J, Yeo T, et al.
J Med Chem
. 2021 Mar;
64(6):3035-3047.
PMID: 33666415
3-Hydroxypropanamidines are a new promising class of highly active antiplasmodial agents. The most active compound exhibited excellent antiplasmodial activity with nanomolar inhibition of chloroquine-sensitive and multidrug-resistant parasite strains of (with...