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Sabine Leh

Explore the profile of Sabine Leh including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 69
Citations 612
Followers 0
Related Specialties
Nephrology
General Surgery
General Medicine
Top 10 Co-Authors
Hans-Peter Marti
Einar Svarstad
Trude Skogstrand
Bjorn Egil Vikse
Oystein Eikrem
Bjarne M Iversen
Michael Hultstrom
Andreas Scherer
Camilla Tondel
Lea Landolt
Published In
Nephrol Dial Transplant
BMC Nephrol
PLoS One
Nephron
Clin J Am Soc Nephrol
Affiliations
Soon will be listed here.
Recent Articles
1.
Norwegian kidney biopsy biobank (NorKiBB): organization, baseline characteristics, and generalizability of a low-cost national biobank
Ovrehus M, Asbjorn K, Langlo R, Leh S, Eikrem O, Romundstad S, et al.
BMC Nephrol . 2025 Feb; 26(1):76. PMID: 39948520
Background: Biobanks that hold blood, urine and kidney tissue are key for translational nephrology research but are few and have limited availability. We describe the organization, baseline characteristics, and generalizability...
2.
Annotation Practices in Computational Pathology: A European Society of Digital and Integrative Pathology (ESDIP) Survey Study
Montezuma D, Oliveira S, Tolkach Y, Boor P, Haragan A, Carvalho R, et al.
Lab Invest . 2024 Nov; 105(3):102203. PMID: 39615882
Integrating digital pathology and artificial intelligence (AI) algorithms can potentially improve diagnostic practice and precision medicine. Developing reliable, generalizable, and comparable AI algorithms depends on access to meticulously annotated data....
3.
Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy
Rivedal M, Mikkelsen H, Marti H, Liu L, Kiryluk K, Knoop T, et al.
Kidney Int . 2023 Dec; 105(4):717-730. PMID: 38154557
Some patients diagnosed with benign IgA nephropathy (IgAN) develop a progressive clinical course, not predictable by known clinical or histopathological parameters. To assess if gene expression can differentiate between progressors...
4.
Transcriptomic analysis reveals partial epithelial-mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy
Nordbo O, Landolt L, Eikrem O, Scherer A, Leh S, Furriol J, et al.
Physiol Rep . 2023 Oct; 11(19):e15825. PMID: 37813528
Hypertensive nephrosclerosis (HN) and Type 2 diabetic nephropathy (T2DN) are the leading causes of chronic kidney disease (CKD). To explore shared pathogenetic mechanisms, we analyzed transcriptomes of kidney biopsies from...
5.
Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts
Kipp A, Marti H, Babickova J, Nakken S, Leh S, Halden T, et al.
BMC Nephrol . 2023 Aug; 24(1):254. PMID: 37626301
Background: Diabetes mellitus (DM), either preexisting or developing after transplantation, remains a crucial clinical problem in kidney transplantation. To obtain insights into the molecular mechanisms underlying PTDM development and early...
6.
A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice
OKeeffe M, Oterhals A, Weishaupt H, Leh S, Ulvik A, Ueland P, et al.
Eur J Nutr . 2023 Aug; 62(8):3227-3240. PMID: 37550593
Purpose: The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a...
7.
Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing
Delaleu N, Marti H, Strauss P, Sekulic M, Osman T, Tondel C, et al.
Kidney Int . 2023 Jul; 104(4):803-819. PMID: 37419447
Fabry disease is a rare disorder caused by variations in the alpha-galactosidase gene. To a degree, Fabry disease is manageable via enzyme replacement therapy (ERT). By understanding the molecular basis...
8.
Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats
Vildmyren I, Oterhals A, Leh S, Samuelsen T, Halstensen A, Marti H, et al.
Food Nutr Res . 2022 Nov; 66. PMID: 36340918
Background: Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary objective of...
9.
Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up
Gjerstad A, Skrunes R, Tondel C, Asberg A, Leh S, Klingenberg C, et al.
Pediatr Nephrol . 2022 Aug; 38(4):1249-1256. PMID: 35994104
Background: There is scarce information on biopsy-verified kidney disease in childhood and its progression to chronic kidney disease stage 5 (CKD 5). This study aims to review biopsy findings in...
10.
Focal segmental glomerulosclerosis and proteinuria associated with Myo1E mutations: novel variants and histological phenotype analysis
Krendel M, Leh S, Garone M, Edwards-Richards A, Lin J, Brackman D, et al.
Pediatr Nephrol . 2022 Jun; 38(2):439-449. PMID: 35723736
Background: Pathogenic mutations in the non-muscle single-headed myosin, myosin 1E (Myo1e), are a rare cause of pediatric focal segmental glomerulosclerosis (FSGS). These mutations are biallelic, to date only reported as...