Norwegian Kidney Biopsy Biobank (NorKiBB): Organization, Baseline Characteristics, and Generalizability of a Low-cost National Biobank

Overview

Journal BMC Nephrol

Publisher Biomed Central

Specialty Nephrology

Date 2025 Feb 13

PMID 39948520

Authors

Marius Altern Ovrehus

Knut Asbjorn

Rise Langlo

Sabine Leh

Oystein Eikrem

Solfrid Romundstad

Havard Aksnes

Ingjerd Wangensteen Manner

Christian Aalborg

Marit D Solbu

Lasse G Goransson

Hans-Peter Marti

Michael G Shlipak

Joachim H Ix

Stein I Hallan

Affiliations

Soon will be listed here.

Abstract

Background: Biobanks that hold blood, urine and kidney tissue are key for translational nephrology research but are few and have limited availability. We describe the organization, baseline characteristics, and generalizability of a low-cost national biobank.

Materials And Methods: Eight Norwegian hospitals participated in this multi-center, prospective cohort study and biobank initiative. Patients referred for routine clinical native kidney biopsies were eligible for inclusion, starting September 2020. Extensive information on medical history and risk factors were collected into an encrypted on-line database by the treating nephrologist. A comprehensive standardized panel of blood and urine tests were analyzed in the clinical routine and registered along with the full histology report. Extra urine and blood samples were collected, aliquoted and prepared locally within two hours, frozen at -80 C, and later sent to a central government-funded biorepository together with remaining kidney biopsy material.

Results: By September 2023, a total of 633 patients were included out of 1050 eligible patients. Mean age was 52.6 years (SD 18.7), 384 (61%) were men, and participants displayed a wide spectrum of kidney disease with mean estimated glomerular filtration rate (eGFR) 53 mL/min/1.73m. The most frequent biopsy indications were progressive chronic kidney disease (CKD) of unknown cause, acute kidney disease, and isolated hematuria/proteinuria. The most frequent diagnoses were IgA nephropathy (21%), arterionephrosclerosis (13%), and diabetes nephropathy (9%). Biopsy indications and diagnoses were similar to the spectrum typically seen in Norway and other western countries, and similar population level kidney health measures were demonstrated for Norway, United Kingdom, and USA.

Discussion: We demonstrate the feasibility of establishing a large national kidney biopsy biobank across a variety of clinical and histopathologic diagnoses. Blood and urine were stored, accompanied by kidney tissue, at a moderate cost due to a combination of a dedicated nephrology workforce, routine clinical care, and established biobank facilities.

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