Sabin Llona-Minguez
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Explore the profile of Sabin Llona-Minguez including associated specialties, affiliations and a list of published articles.
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21
Citations
232
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Recent Articles
1.
Zhang S, Paulin C, Shu H, Yague-Capilla M, Michel M, Marttila P, et al.
iScience
. 2024 Feb;
27(2):108907.
PMID: 38318365
SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To understand SAMHD1 biology and investigate the potential of targeting SAMHD1 as...
2.
Bonagas N, Gustafsson N, Henriksson M, Marttila P, Gustafsson R, Wiita E, et al.
Nat Cancer
. 2022 Mar;
3(2):156-172.
PMID: 35228749
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In...
3.
Page B, Valerie N, Wright R, Wallner O, Isaksson R, Carter M, et al.
Nat Commun
. 2019 Nov;
10(1):5050.
PMID: 31676755
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
4.
Llona-Minguez S, Ghassemian A, Baranczewski P, Desroses M, Koolmeister T, Artursson P, et al.
Medchemcomm
. 2018 Aug;
8(7):1553-1560.
PMID: 30108867
In this study, we provide insight into the metabolic profile of a series of piperazin-1-ylpyridazines suffering from rapid intrinsic clearance in a metabolic stability assay using liver microsomes ( compound...
5.
Page B, Valerie N, Wright R, Wallner O, Isaksson R, Carter M, et al.
Nat Commun
. 2018 Jan;
9(1):250.
PMID: 29343827
With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine metabolism and...
6.
Llona-Minguez S, Throup A, Steiner E, Lightowler M, Van der Haegen S, Homan E, et al.
Org Biomol Chem
. 2017 Sep;
15(37):7758-7764.
PMID: 28891572
Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the...
7.
Llona-Minguez S, Hoglund A, Ghassemian A, Desroses M, Calderon-Montano J, Burgos Moron E, et al.
J Med Chem
. 2017 Sep;
60(17):7614.
PMID: 28862438
No abstract available.
8.
Llona-Minguez S, Fayezi S, Alihemmati A, Juarez-Jimenez J, Piedrafita F, Helleday T
Bioorg Med Chem Lett
. 2017 Aug;
27(18):4462-4466.
PMID: 28807439
A series of tetrahydrobenzothiophene carboxamides, inspired by structural features present in kinase and SCD1 inhibitors, are presented here. Prototype compound 8 (MMDD13) modulates fatty acid elongase and desaturase indexes, lipid...
9.
Anthony N, Baiget J, Berretta G, Boyd M, Breen D, Edwards J, et al.
J Med Chem
. 2017 Jul;
60(16):7043-7066.
PMID: 28737909
IKKβ plays a central role in the canonical NF-kB pathway, which has been extensively characterized. The role of IKKα in the noncanonical NF-kB pathway, and indeed in the canonical pathway...
10.
Llona-Minguez S, Haggblad M, Martens U, Throup A, Loseva O, Jemth A, et al.
Bioorg Med Chem Lett
. 2017 Jul;
27(16):3897-3904.
PMID: 28687206
A high-throughput screening campaign using a commercial compound library (ChemBridge DiverSET) revealed diverse chemotypes as inhibitors of the human dCTP pyrophosphatase 1 (dCTPase). Triazole, triazolopyrimidine, triazinoindole, quinoline hydrazone and arylpiperazine...