Sabin Llona-Minguez
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Explore the profile of Sabin Llona-Minguez including associated specialties, affiliations and a list of published articles.
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21
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232
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Recent Articles
11.
Llona-Minguez S, Haggblad M, Martens U, Johansson L, Sigmundsson K, Lundback T, et al.
Bioorg Med Chem Lett
. 2017 Jun;
27(15):3219-3225.
PMID: 28655422
Two screening campaigns using commercial (Chembridge DiverSET) and proprietary (Chemical Biology Consortium Sweden, CBCS) compound libraries, revealed a number of pyridone- and pyrimidinone-derived systems as inhibitors of the human dCTP...
12.
Llona-Minguez S, Hoglund A, Ghassemian A, Desroses M, Calderon-Montano J, Burgos Moron E, et al.
J Med Chem
. 2017 May;
60(10):4279-4292.
PMID: 28508636
The dCTP pyrophosphatase 1 (dCTPase) is a nucleotide pool "housekeeping" enzyme responsible for the catabolism of canonical and noncanonical nucleoside triphosphates (dNTPs) and has been associated with cancer progression and...
13.
Llona-Minguez S, Hoglund A, Wiita E, Almlof I, Mateus A, Calderon-Montano J, et al.
J Med Chem
. 2017 Feb;
60(5):2148-2154.
PMID: 28145708
The dCTP pyrophosphatase 1 (dCTPase) is involved in the regulation of the cellular dNTP pool and has been linked to cancer progression. Here we report on the discovery of a...
14.
Gustafsson R, Jemth A, Gustafsson N, Farnegardh K, Loseva O, Wiita E, et al.
Cancer Res
. 2016 Dec;
77(4):937-948.
PMID: 27899380
To sustain their proliferation, cancer cells become dependent on one-carbon metabolism to support purine and thymidylate synthesis. Indeed, one of the most highly upregulated enzymes during neoplastic transformation is MTHFD2,...
15.
Llona-Minguez S, Hoglund A, Jacques S, Johansson L, Calderon-Montano J, Claesson M, et al.
J Med Chem
. 2016 Jan;
59(3):1140-1148.
PMID: 26771665
The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs). dCTPase is highly expressed in multiple carcinomas and is associated...
16.
Llona-Minguez S, Desroses M, Ghassemian A, Jacques S, Eriksson L, Isacksson R, et al.
Chemistry
. 2015 Mar;
21(20):7394-8.
PMID: 25809883
A two-step synthesis of structurally diverse pyrrole-containing bicyclic systems is reported. ortho-Nitro-haloarenes coupled with vinylic N-methyliminodiacetic acid (MIDA) boronates generate ortho-vinyl-nitroarenes, which undergo a "metal-free" nitrene insertion, resulting in a...
17.
Llona-Minguez S, Ghassemian A, Helleday T
Prog Lipid Res
. 2015 Feb;
58:51-75.
PMID: 25704399
Lysophosphatidic acids (LPA) are key lipid-signalling molecules that regulate a remarkably diverse set of cellular events, such as motility, chemotaxis, cell cycle progression, viability, and wound healing. The physiological and...
18.
Llona-Minguez S, Mackay S
Beilstein J Org Chem
. 2014 Jul;
10:1333-8.
PMID: 24991286
A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues...
19.
Llona-Minguez S, Hoglund A, Jacques S, Koolmeister T, Helleday T
Expert Rev Mol Med
. 2014 May;
16:e10.
PMID: 24810715
ATR protein kinase is one of the key players in maintaining genome integrity and coordinating of the DNA damage response and repair signalling pathways. Inhibition of ATR prevents signalling from...
20.
Llona-Minguez S, Baiget J, Mackay S
Pharm Pat Anal
. 2013 Nov;
2(4):481-98.
PMID: 24237125
The transcription factors NF-κB and IFN control important signaling cascades and mediate the expression of a number of important pro-inflammatory cytokines, adhesion molecules, growth factors and anti-apoptotic survival proteins. IκB...