Saaid Safieddine
Overview
Explore the profile of Saaid Safieddine including associated specialties, affiliations and a list of published articles.
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35
Citations
1488
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Recent Articles
11.
Schilder A, Su M, Blackshaw H, Lustig L, Staecker H, Lenarz T, et al.
Otol Neurotol
. 2019 May;
40(5):559-570.
PMID: 31083073
Objective: To provide an overview of biotechnology and pharmaceutical companies active in the field of inner ear and central hearing disorders and their therapeutic approaches. Methods: Scientific and grey literature...
12.
Tertrais M, Bouleau Y, Emptoz A, Belleudy S, Sutton R, Petit C, et al.
J Neurosci
. 2019 Mar;
39(18):3394-3411.
PMID: 30833506
Transmitter release at auditory inner hair cell (IHC) ribbon synapses involves exocytosis of glutamatergic vesicles during voltage activation of L-type Ca1.3 calcium channels. At these synapses, the fast and indefatigable...
13.
Akil O, Dyka F, Calvet C, Emptoz A, Lahlou G, Nouaille S, et al.
Proc Natl Acad Sci U S A
. 2019 Feb;
116(10):4496-4501.
PMID: 30782832
Autosomal recessive genetic forms (DFNB) account for most cases of profound congenital deafness. Adeno-associated virus (AAV)-based gene therapy is a promising therapeutic option, but is limited by a potentially short...
14.
Johnson S, Safieddine S, Mustapha M, Marcotti W
Cold Spring Harb Perspect Med
. 2019 Jan;
9(12).
PMID: 30617058
To provide a meaningful representation of the auditory landscape, mammalian cochlear hair cells are optimized to detect sounds over an incredibly broad range of frequencies and intensities with unparalleled accuracy....
15.
Calvet C, Lahlou G, Safieddine S
Med Sci (Paris)
. 2018 Nov;
34(10):842-848.
PMID: 30451679
Hearing and balance impairment are major concerns and a serious public health burden, as it affects millions of people worldwide, but still lacks an effective curative therapy. Recent breakthroughs in...
16.
Corns L, Johnson S, Roberts T, Ranatunga K, Hendry A, Ceriani F, et al.
Nat Commun
. 2018 Oct;
9(1):4015.
PMID: 30275467
In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels...
17.
Dulon D, Papal S, Patni P, Cortese M, Vincent P, Tertrais M, et al.
J Clin Invest
. 2018 Jul;
128(8):3382-3401.
PMID: 29985171
Clarin-1, a tetraspan-like membrane protein defective in Usher syndrome type IIIA (USH3A), is essential for hair bundle morphogenesis in auditory hair cells. We report a new synaptic role for clarin-1...
18.
Michalski N, Goutman J, Auclair S, de Monvel J, Tertrais M, Emptoz A, et al.
Elife
. 2017 Nov;
6.
PMID: 29111973
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C-domain, Ca-binding...
19.
Emptoz A, Michel V, Lelli A, Akil O, de Monvel J, Lahlou G, et al.
Proc Natl Acad Sci U S A
. 2017 Aug;
114(36):9695-9700.
PMID: 28835534
Our understanding of the mechanisms underlying inherited forms of inner ear deficits has considerably improved during the past 20 y, but we are still far from curative treatments. We investigated...
20.
Vincent P, Bouleau Y, Charpentier G, Emptoz A, Safieddine S, Petit C, et al.
J Neurosci
. 2017 Feb;
37(11):2960-2975.
PMID: 28193694
The mechanisms orchestrating transient and sustained exocytosis in auditory inner hair cells (IHCs) remain largely unknown. These exocytotic responses are believed to mobilize sequentially a readily releasable pool of vesicles...